KCNA6 - potassium voltage-gated channel subfamily A member 6 Gene

Homo sapiens

Also known as HBK2; KV1.6; PPP1R96

Gene ID: 3742 | Gene type: protein coding

About KCNA6

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,809,334-4,851,112 (from NCBI)

This gene has 1 transcript (splice variant), 82 orthologues and 31 paralogues. Biased expression in brain (RPKM 7.0), adrenal (RPKM 1.0) and 4 other tissues.

Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related Potassium Channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the Potassium Channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]

KCNA6 Products(1)

mRNA	Protein	Name
NM_002235.5	NP_002226.1	potassium voltage-gated channel subfamily A member 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	2347305	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	14575698	GOA
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	36318112	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	2347305	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	14575698	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	2347305	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNA6 Protein Structure

BTB_2

Ion_trans

0
100
200
300
400
500
529 a.a.

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily A member 6

human brain potassium channel-2

KCNA6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KCNA6	P17658	DOLK	Homo sapiens	Q9UPQ8	Anti Tag CoIP	33961781
Intra	KCNA6	P17658	DOLK	Homo sapiens	Q9UPQ8	Anti Tag CoIP	28514442
Intra	KCNA6	P17658	DOLK	Homo sapiens	Q9UPQ8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07102	KCNA6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KCNA6	RGD	RGD:62083
Mus musculus	KCNA6	MGD	MGI:96663
Canis familiaris	KCNA6	VGNC	VGNC:57428
Bos taurus	KCNA6	VGNC	VGNC:56213
Felis catus	KCNA6	VGNC	VGNC:84043
Macaca mulatta	KCNA6	VGNC	VGNC:108354

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