KCNF1 - potassium voltage-gated channel modifier subfamily F member 1 Gene

Homo sapiens

Also known as IK8; kH1; KCNF; KV5.1

Gene ID: 3754 | Gene type: protein coding

About KCNF1

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,911,934-10,914,225 (from NCBI)

This gene has 1 transcript (splice variant), 241 orthologues and 31 paralogues.

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008]

KCNF1 Products(1)

mRNA	Protein	Name
NM_002236.5	NP_002227.2	potassium voltage-gated channel subfamily F member 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNF1 Protein Structure

BTB_2

Ion_trans

0
100
200
300
400
494 a.a.

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily F member 1

potassium channel KH1

KCNF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KCNF1	Q9H3M0	SERP1	Homo sapiens	Q9Y6X1	Complementation	32296183
Intra	KCNF1	Q9H3M0	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Arts Syndrome

ARTS	Mrxsarts
Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision	Mrxs18
Lethal Ataxia With Deafness And Optic Atrophy	Fatal X-Linked Ataxia With Deafness And Loss Of Vision
Mental Retardation, X-Linked, Syndromic, Arts Type	Mental Retardation, X-Linked, Syndromic 18
Syndromic X-Linked Mental Retardation 18	Syndromic X-Linked Mental Retardation Arts Type
Lethal Ataxia-Deafness-Optic Atrophy	X-Linked Fatal Ataxia With Deafness And Loss Of Vision
Ataxia-Deafness-Optic Atrophy, Lethal	Lethal Ataxia With Hearing Loss And Optic Atrophy
Art

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07120	KCNF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KCNF1	VGNC	VGNC:67905
Bos taurus	KCNF1	VGNC	VGNC:30441
Rattus norvegicus	KCNF1	RGD	RGD:631414
Mus musculus	KCNF1	MGD	MGI:2687399
Canis familiaris	KCNF1	VGNC	VGNC:42244

Name
Email *

	Sorry, but the email address you supplied was invalid.