SIMC1 - SUMO interacting motifs containing 1 Gene

Homo sapiens

Also known as OOMA1; PLEIAD; C5orf25

Gene ID: 375484 | Gene type: protein coding

About SIMC1

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,238,424-176,345,989 (from NCBI)

This gene has 11 transcripts (splice variants), 186 orthologues and 2 paralogues. Broad expression in testis (RPKM 8.3), ovary (RPKM 7.8) and 23 other tissues.

Summary

Enables SUMO polymer binding activity and peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Located in sarcomere. [provided by Alliance of Genome Resources, Apr 2022]

SIMC1 Products(4)

mRNA	Protein	Name
NM_001308195.2	NP_001295124.1	SUMO-interacting motif-containing protein 1 isoform a
NM_001308196.2	NP_001295125.1	SUMO-interacting motif-containing protein 1 isoform c
NM_001308200.2	NP_001295129.1	SUMO-interacting motif-containing protein 1 isoform d
NM_198567.6	NP_940969.3	SUMO-interacting motif-containing protein 1 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO polymer binding	IDA IDA: Inferred from direct assay	23086935	GOA
enables peptidase inhibitor activity	IDA IDA: Inferred from direct assay	23707407	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21900206	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	36373674	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23707407	GOA
located in sarcomere	IDA IDA: Inferred from direct assay	23707407	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SUMO-interacting motif-containing protein 1

oocyte maturation associated 1

Related Diseases

Diseases

Alias

Mucopolysaccharidosis, Type Iiid

Mucopolysaccharidosis Type Iiid	MPS3D
Mps Iiid	N-Acetylglucosamine-6-Sulfatase Deficiency
Sanfilippo Syndrome D	Gns Deficiency
Mucopolysaccharidosis Type 3d	Sanfilippo Syndrome Type D
Glucosamine N-Acetyl-6-Sulfatase Deficiency	Mpsiiid
Mps 3d	Mucopoly-Saccharidosis Type 3d
N-Acetylglucosamine-6-Sulfate Sulfatase Deficiency	Mps Iii-D
Mucopolysaccharidosis 3d	Sanfilippo D Syndrome
Mps Iii D

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12924	SIMC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIMC1	MGD	MGI:2442599
Rattus norvegicus	SIMC1	RGD	RGD:2319689
Felis catus	SIMC1	VGNC	VGNC:65149
Canis familiaris	SIMC1	VGNC	VGNC:46176
Bos taurus	SIMC1	VGNC	VGNC:54482
Macaca mulatta	SIMC1	VGNC	VGNC:77304

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