SLF2 - SMC5-SMC6 complex localization factor 2 Gene

Homo sapiens

Also known as C10orf6; FAM178A

Gene ID: 55719 | Gene type: protein coding

About SLF2

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,912,963-100,965,134 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 1 paralogue. Broad expression in testis (RPKM 12.5), ovary (RPKM 7.5) and 24 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in chromatin; nucleoplasm; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SLF2 Products(3)

mRNA	Protein	Name
NM_001136123.2	NP_001129595.1	SMC5-SMC6 complex localization factor protein 2 isoform 2
NM_001243770.2	NP_001230699.1	SMC5-SMC6 complex localization factor protein 2 isoform 3
NM_018121.4	NP_060591.3	SMC5-SMC6 complex localization factor protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25931565	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	25931565	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25931565	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	25931565	GOA
involved in positive regulation of double-strand break repair	IDA IDA: Inferred from direct assay	25931565	GOA
involved in positive regulation of maintenance of mitotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	25931565	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	25931565	GOA
involved in protein localization to site of double-strand break	IDA IDA: Inferred from direct assay	25931565	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	36373674	GOA
located in chromatin	IDA IDA: Inferred from direct assay	24561620	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24561620	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	25931565	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLF2 Protein Structure

FAM178

0
200
400
600
800
1000
1173 a.a.

Protein Preferred Names

Protein Names

SMC5-SMC6 complex localization factor protein 2

family with sequence similarity 178, member A

SLF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLF2	Q8IX21	SLF1	Homo sapiens	Q9BQI6	Anti Tag CoIP	36373674
Intra	SLF2	Q8IX21	SLF1	Homo sapiens	Q9BQI6	Anti Tag CoIP	26496610
Intra	SLF2	Q8IX21	SLF1	Homo sapiens	Q9BQI6	Y2H	32389690
Intra	SLF2	Q8IX21	TRIM14	Homo sapiens	Q14142	Y2H Array	32296183
Intra	SLF2	Q8IX21	TRIM14	Homo sapiens	Q14142	Y2H Prey Pooling	32296183
Intra	SLF2	Q8IX21	SMC5	Homo sapiens	Q8IY18	Anti Tag CoIP	33961781
Intra	SLF2	Q8IX21	SMC5	Homo sapiens	Q8IY18	Y2H	32389690
Intra	SLF2	Q8IX21	SMC6	Homo sapiens	Q96SB8	Anti Tag CoIP	33961781
Intra	SLF2	Q8IX21	SMC6	Homo sapiens	Q96SB8	Y2H	32389690
Intra	SLF2	Q8IX21	SIMC1	Homo sapiens	Q8NDZ2	Pull Down	36373674
Intra	SLF2	Q8IX21	SIMC1	Homo sapiens	Q8NDZ2	Anti Tag CoIP	36373674
Intra	SLF2	Q8IX21	SIMC1	Homo sapiens	Q8NDZ2	GMS	36373674
Intra	SLF2	Q8IX21	SIMC1	Homo sapiens	Q8NDZ2	Confocal	36373674
Intra	SLF2	Q8IX21	SIMC1	Homo sapiens	Q8NDZ2	Anti Tag CoIP	33961781
Intra	SLF2	Q8IX21	SIMC1	Homo sapiens	Q8NDZ2	3D-EM	36373674

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Form Agnosia

Alveoli Adenoma

Alveolar Adenoma	Adenoma Of Alveoli
Adenoma Of The Alveoli

Bronchial Benign Neoplasm

Bronchus Neoplasm	Neoplasm Of Bronchus
Bronchial Neoplasms	Bronchial Neoplasm

Papillorenal Syndrome

Renal Coloboma Syndrome	Coloboma Of Optic Nerve With Renal Disease
Renal-Coloboma Syndrome	Optic Nerve Coloboma With Renal Disease
Optic Coloboma, Vesicoureteral Reflux, And Renal Anomalies	Renal-Coloboma Syndrome With Macular Abnormalities
Congenital Anomalies Of The Kidney And Urinary Tract With Or Without Ocular Abnormalities	Cakut With Or Without Ocular Abnormalities
PAPRS	Optic Coloboma, Vesicoureteral Reflux And Renal Anomalies
Papillo-Renal Syndrome, Optic Nerve Coloboma With Renal Disease	Coloboma-Ureteral-Renal Syndrome
Oncr	Optic Nerve Coloboma Renal Syndrome
Rcs	Papillo-Renal Syndrome
Optic Coloboma Vesicoureteral Reflux And Renal Anomalies

Mitochondrial Dna Depletion Syndrome 7

Ohaha Syndrome	Infantile Onset Spinocerebellar Ataxia
Iosca	Infantile-Onset Spinocerebellar Ataxia
Spinocerebellar Ataxia 8	MTDPS7
Ophthalmoplegia, Hypotonia, Ataxia, Hypacusis, And Athetosis	Ophthalmoplegia-Hypotonia-Ataxia-Hypoacusis-Athetosis Syndrome
Sca8	Spinocerebellar Ataxia Infantile With Sensory Neuropathy
Spinocerebellar Ataxia, Infantile-Onset	Ophthalmoplegia, Hypotonia, Ataxia, Hypoacusis, And Athetosis
Spinocerebellar Ataxia, Infantile, With Sensory Neuropathy	Spinocerebellar Ataxia 8, Formerly
Sca8, Formerly	Iosca, Mitochondrial Dna Depletion Syndrome 7
Ophthalmoplegia - Hypotonia - Ataxia - Hypoacusis - Athetosis	Mitochondrial Dna Depletion Syndrome, Hepatocerebrorenal Form
Mtdna Depletion Syndrome, Hepatocerebrorenal Form	Mitochondrial Dna Depletion Syndrome 7 Hepatocerebral Type
Ophthalmoplegia Hypotonia Ataxia Hypoacusis And Athetosis	Pure Spinocerebellar Ataxia Japanese Type
Sca4 Pure Japanese Type	Spinocerebellar Ataxia Infantile-Onset
Mitochondrial Dna Depletion Syndrome , Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13362	SLF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLF2	VGNC	VGNC:106104
Rattus norvegicus	SLF2	RGD	RGD:1560300
Mus musculus	SLF2	MGD	MGI:1924968
Canis familiaris	SLF2	VGNC	VGNC:53013
Felis catus	SLF2	VGNC	VGNC:107070
Bos taurus	SLF2	VGNC	VGNC:34958

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