KCNJ11 - potassium inwardly rectifying channel subfamily J member 11 Gene

Homo sapiens

Also known as BIR; HHF2; PHHI; IKATP; PNDM2; TNDM3; KIR6.2; MODY13

Gene ID: 3767 | Gene type: protein coding

About KCNJ11

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,385,248-17,389,346 (from NCBI)

This gene has 7 transcripts (splice variants), 195 orthologues, 15 paralogues and is associated with 15 phenotypes. Broad expression in brain (RPKM 2.5), thyroid (RPKM 2.3) and 20 other tissues.

Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type Potassium Channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated Insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]

KCNJ11 Products(4)

mRNA	Protein	Name
NM_000525.4	NP_000516.3	ATP-sensitive inward rectifier potassium channel 11 isoform 1
NM_001166290.2	NP_001159762.1	ATP-sensitive inward rectifier potassium channel 11 isoform 2
NM_001377296.1	NP_001364225.1	ATP-sensitive inward rectifier potassium channel 11 isoform 2
NM_001377297.1	NP_001364226.1	ATP-sensitive inward rectifier potassium channel 11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ankyrin binding	IPI IPI: Inferred from physical interaction	20610380	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19805355	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	20610380	GOA
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	18945825	GOA
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	18945825	GOA
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	19805355	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	8923010	GOA
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	8923010	GOA
involved in nervous system process	IMP IMP: Inferred from mutant phenotype	15115830	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	19805355	GOA
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	15115830	GOA
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	18073297	GOA
involved in response to ATP	IDA IDA: Inferred from direct assay	15583126	GOA
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	18073297	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of inward rectifying potassium channel	IDA IDA: Inferred from direct assay	19805355	GOA
part of inward rectifying potassium channel	IPI IPI: Inferred from physical interaction	29286281	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19805355	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNJ11 Protein Structure

IRK

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

ATP-sensitive inward rectifier potassium channel 11

beta-cell inward rectifier subunit

Related Diseases

Diseases

Alias

Hyperinsulinemic Hypoglycemia, Familial, 2

Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Familial Hyperinsulinism	Congenital Hyperinsulinism
HHF2	Nesidioblastosis
Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia	Familial Hyperinsulinemic Hypoglycemia 2
Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency	Chi
Congenital Isolated Hyperinsulinism	Hyperinsulinemic Hypoglycemia, Persistent
Hyperinsulinism, Neonatal	Hyperinsulinism, Congenital
Hyperinsulinism, Familial	Hyperinsulinemic Hypoglycemia Familial
Hyperinsulinism Congenital	Hyperinsulinism Familial With Pancreatic Nesidioblastosis
Hypoglycemia Hyperinsulinemic Of Infancy	Nesidioblastosis Of Pancreas
Hyperinsulinemic Hypoglycemia Familial 2	Hyperinsulinemia Hypoglycemia Of Infancy
Infancy Hyperinsulinemia Hypoglycemia	Neonatal Hyperinsulinism
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Persistent Hyperinsulinemic Hypoglycemia
Phhi Hypoglycemia	Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency	Dominant Katp Hyperinsulinism Due To Kir6.2 Deficiency
Diazoxide-Resistant Focal Hyperinsulinism Due To Kir6.2 Deficiency	Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency, Diazoxide-Resistant Focal Form
Fhi	Familial Hyperinsulinemic Hypoglycemia
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency	Hypoglycemia, Hyperinsulinemic, Familial, Type 2
Hi-C

Diabetes Mellitus, Permanent Neonatal, 2

Diabetes, Permanent Neonatal 2, With Or Without Neurologic Features	PNDM2
Diabetes Mellitus, Permanent Neonatal 2	Dend1
Developmental Delay, Epilepsy, And Neonatal Diabetes 1

Maturity-Onset Diabetes Of The Young, Type 13

Maturity-Onset Diabetes Of The Young Type 13	MODY13
Mody Type 13	Mody, Type 13
Maturity-Onset Diabetes Of The Young 13	Diabetes Of The Young, Maturity-Onset, Type 13

Diabetes Mellitus, Transient Neonatal, 3

TNDM3	Diabetes Mellitus, Transient Neonatal 3
Transient Neonatal Diabetes Mellitus 3

Permanent Neonatal Diabetes Mellitus

Pndm	Permanent Diabetes Mellitus Of Infancy
Pdmi	Neonatal Diabetes Mellitus, Permanent

Diabetes Mellitus

Diabetes

Neonatal Diabetes

Neonatal Diabetes Mellitus	Diabetes Mellitus Syndrome In Newborn Infant
Ndm

Diabetes Mellitus, Permanent Neonatal, 1

PNDM1	Pdmi
Dend Syndrome	Permanent Diabetes Mellitus Of Infancy
Permanent Neonatal Diabetes Mellitus 1	Diabetes Mellitus, Permanent, Of Infancy
Diabetes Mellitus, Permanent Neonatal 1	Developmental Delay-Epilepsy-Neonatal Diabetes Syndrome
Dend	Developmental Delay Epilepsy And Neonatal Diabetes
Diabetes Mellitus Permanent Neonatal With Neurologic Features	Diabetes Mellitus, Permanent Neonatal, Type 1

Pancreatic Beta Cell Agenesis With Neonatal Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent, Neonatal

Neonatal Insulin-Dependent Diabetes Mellitus

Intermediate Dend Syndrome

Developmental Delay-Epilepsy-Neonatal Diabetes Syndrome, Intermediate Form

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Hyperinsulinemic Hypoglycemia

Nesidioblastosis	Islet Cell Hyperplasia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Hyperinsulinemic Hypoglycaemia

Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1	Persistent Hyperinsulinemic Hypoglycemia Of Infancy
Familial Hyperinsulinemic Hypoglycemia 1	Congenital Hyperinsulinism
Phhi	Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Of Infancy	Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia
Nesidioblastosis Of Pancreas	Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis
Hyperinsulinism, Congenital	Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency	Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form
Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency	Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal	Tndm
Chromosome 6-Associated Transient Diabetes Mellitus	Dmtn
Diabetes Mellitus, 6q24-Related Transient Neonatal	Tndm1
Neonatal Diabetes Mellitus, Transient	Tndm -[Transient Neonatal Diabetes Mellitus]

Isolated Permanent Neonatal Diabetes Mellitus

Isolated Pndm

Monogenic Diabetes Of Infancy

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Hyperinsulinism

Hyperinsulinemia

Gestational Diabetes

Gestational Diabetes Mellitus	GDM
Diabetes Mellitus Arising In Pregnancy	Maternal Gestational Diabetes Mellitus
Diabetes Mellitus, Gestational	Diabetes Mellitus, Pregnancy Related
Diabetes, Pregnancy-Induced	Diabetes Gestational
Diabetes, Gestational	Diabetes Of Pregnancy
Gdm - [Gestational Diabetes Mellitus]	Gestational Diabetes Mellitus Nos
Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium

Hypertrichosis

Monogenic Diabetes

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Cantu Syndrome

Hypertrichotic Osteochondrodysplasia	Hypertrichotic Osteochondrodysplasia Cantu Type
Cantú Syndrome	Craniofaciocardioskeletal Syndrome
Hypertrichosis-Osteochondrodysplasia-Cardiomegaly Syndrome	Congenital Hypertrichosis-Acromegaloid Facial Features Spectrum
Congenital Hypertrichosis-Coarse Facial Features Spectrum	HTOCD
Osteochondrodysplasia, Hypertrichotic

Hyperglycemia

Cardiomyopathy, Dilated, 1o

Dilated Cardiomyopathy 1o	CMD1O
Dilated Cardiomyopathy With Ventricular Tachycardia	Cardiomyopathy, Dilated, With Ventricular Tachycardia
Cardiomyopathy, Dilated 1o	Cardiomyopathy, Dilated, Type 1o

Chronic Duodenal Ileus

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Maturity-Onset Diabetes Of The Young, Type 9

Maturity-Onset Diabetes Of The Young Type 9	MODY9
Maturity-Onset Diabetes Of The Young, Type Ix	Maturity-Onset Diabetes Of The Young 9
Mody-9	Mody Type 9
Diabetes Of The Young, Maturity-Onset, Type 9

Maturity-Onset Diabetes Of The Young, Type 11

Maturity-Onset Diabetes Of The Young Type 11	MODY11
Maturity-Onset Diabetes Of The Young 11	Mody-11
Mody Type 11	Diabetes Of The Young, Maturity-Onset, Type 11

Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

Wolcott-Rallison Syndrome	Med-Iddm Syndrome
Iddm-Med Syndrome	Wolcott Rallison Syndrome
WRS	Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus
Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia	Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus

Maturity-Onset Diabetes Of The Young, Type 7

Maturity-Onset Diabetes Of The Young Type 7	MODY7
Maturity-Onset Diabetes Of The Young, Type Vii	Maturity-Onset Diabetes Of The Young 7
Mody-7	Mody Type 7
Diabetes Of The Young, Maturity-Onset, Type 7

Maturity-Onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction

Maturity-Onset Diabetes Of The Young Type 8	MODY8
Dped	Maturity-Onset Diabetes Of The Young, Type Viii
Mody Type 8	Diabetes And Pancreatic Exocrine Dysfunction
Diabetes-Pancreatic Exocrine Dysfunction Syndrome	Diabetes And Pancreatic Exocrine
Maturity-Onset Diabetes Of The Young Type 8 With Exocrine Dysfunction	Maturity-Onset Diabetes Of The Young 8 With Exocrine Dysfunction
Diabetes And Pancreatic Exocrine Dysfunction Syndrome	Mody-8
Diabetes Of The Young, Maturity-Onset, Type 8

Wolfram Syndrome 1

WFS1	Didmoad
Wfs	Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome
Wolfram Syndrome

Maturity-Onset Diabetes Of The Young, Type 14

Maturity-Onset Diabetes Of The Young Type 14	MODY14
Maturity-Onset Diabetes Of The Young 14	Diabetes Of The Young, Maturity-Onset, Type 14

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Maturity-Onset Diabetes Of The Young, Type 2

Maturity-Onset Diabetes Of The Young Type 2	MODY2
Mody Glucokinase-Related	Mody Type 2
Mody, Type 2	Mody, Glucokinase-Related
Mody, Type Ii	Maturity-Onset Diabetes Of The Young 2
Mody-2	Diabetes Of The Young, Maturity-Onset, Type 2
Diabetes Mellitus Autosomal Dominant Type Ii

Munchausen By Proxy

Munchausen Syndrome By Proxy	Munchausen By Proxy Syndrome
Münchausen Syndrome By Proxy

Maturity-Onset Diabetes Of The Young, Type 10

Maturity-Onset Diabetes Of The Young Type 10	MODY10
Maturity-Onset Diabetes Of The Young 10	Mody-10
Mody Type 10	Diabetes Of The Young, Maturity-Onset, Type 10

Maturity-Onset Diabetes Of The Young, Type 1

Maturity-Onset Diabetes Of The Young Type 1	MODY1
Mild Juvenile Diabetes Mellitus	Mody, Type I
Diabetes Mellitus Type 2	Mody Type 1
Mody, Type 1	Maturity-Onset Diabetes Of The Young 1
Mody-1	Diabetes Of The Young, Maturity-Onset, Type 1

Maturity-Onset Diabetes Of The Young, Type 4

Maturity-Onset Diabetes Of The Young Type 4	MODY4
Mody, Type Iv	Mody Type 4
Mody, Type 4	Maturity-Onset Diabetes Of The Young 4
Mody-4	Diabetes Of The Young, Maturity-Onset, Type 4
Maturity-Onset Diabetes Of The Young, Type Iv

Maturity-Onset Diabetes Of The Young, Type 6

MODY6	Maturity-Onset Diabetes Of The Young Type 6
Maturity-Onset Diabetes Of The Young 6	Mody Type 6
Mody, Type 6	Mody-6
Diabetes Of The Young, Maturity-Onset, Type 6

Maturity-Onset Diabetes Of The Young, Type 3

Maturity-Onset Diabetes Of The Young Type 3	MODY3
Mody, Type Iii	Mody Type 3
Mody, Type 3	Maturity-Onset Diabetes Of The Young 3
Mody-3	Diabetes Of The Young, Maturity-Onset, Type 3

Hyperinsulinemic Hypoglycemia, Familial, 6

Hyperinsulinism-Hyperammonemia Syndrome	HHF6
Familial Hyperinsulinemic Hypoglycemia 6	Hi/Ha Syndrome
Ha/Hi Syndrome	Hyperinsulinemic Hypoglycemia Familial 6
Hyperinsulinism Hyperammonemia Syndrome	Hhs

Renal Cysts And Diabetes Syndrome

RCAD	Mody5
Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes	Cakut With Diabetes
Maturity-Onset Diabetes Of The Young Type 5	Tubulointerstitial Kidney Disease, Autosomal Dominant, 3
Adtkd3	Atypical Familial Juvenile Hyperuricemic Nephropathy
Atypical Fjhn	Familial Hypoplastic Glomerulocystic Kidney
Maturity-Onset Diabetes Of The Young, Type 5	Hyperuricemic Nephropathy, Familial Juvenile, Atypical
Fjhn, Atypical	Glomerulocystic Kidney Disease, Hypoplastic Type
Glomerulocystic Kidney, Familial Hypoplastic	Hypoplastic Type Glomerulocystic Kidney Disease
Glomerulocystic Kidney Disease Hypoplastic Type	Renal-Diabetes Mody5 Syndrome

Asphyxia Neonatorum

Birth Asphyxia	Postnatal Asphyxia
Asphyxia - Birth	Asphyxia, In Liveborn Infant
Hypoxia Neonatorum	Hypoxia, In Liveborn Infant
Intrapartum Asphyxia	Neonatal Asphyxia
Newborn Asphyxia	Asphyxia In Liveborn Infant
Asphyxia Of Newborn Nos	Perinatal Asphyxia
Perinatal Hypoxia	Newborn Asphyxiation

Pancreatic Agenesis

Partial Pancreatic Agenesis	Congenital Pancreatic Agenesis
Partial Agenesis Of The Pancreas	Agenesis, Pancreatic
Pancreatic Agenesis, Congenital

Prediabetes Syndrome

Prediabetes	Impaired Glucose Tolerance
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Hyperinsulinemic Hypoglycemia, Familial, 7

HHF7	Exercise-Induced Hyperinsulinemic Hypoglycemia
Exercise-Induced Hyperinsulinism	Familial Hyperinsulinemic Hypoglycemia 7
Eihi	Hyperinsulinism Due To Monocarboxylate Transporter 1 Deficiency
Hyperinsulinism Due To Slc16a1 Deficiency	Hyperinsulinemic Hypoglycemia, Exercise-Induced
Exercise Induced Hyperinsulinemic Hypoglycemia	Hyperinsulinemic Hypoglycemia Exercise-Induced
Hyperinsulinemic Hypoglycemia Familial 7

Factitious Disorder

Munchausen Syndrome	Factitious Disorders
Münchausen Syndrome

Hypoglycemia, Leucine-Induced

Leucine-Sensitive Hypoglycemia Of Infancy	Leucine-Induced Hypoglycemia
LIH	Hypoglycemia Of Infancy, Leucine-Sensitive
Familial Infantile Hypoglycemia Precipitated By Leucine	Hypoglycemia Leucine Induced
Hypoglycemia Leucine-Induced

Developmental Coordination Disorder

Motor Skills Disorders

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis	KPD
Diabetes Mellitus, Ketosis-Prone, Susceptibility To	Ketosis-Prone Diabetes Mellitus
Diabetes Mellitus, Insulin-Dependent	Diabetic Ketoacidosis Nos
Dka - [Diabetic Ketoacidosis] Nos	Dka - [Diabetic Ketoacidosis] Without Coma
Dka - [Diabetic Ketoacidosis] With Coma

Coronary Artery Vasospasm

Coronary Vasospasm

Coronary Artery Spasm

Fetal Erythroblastosis

Erythroblastosis, Fetal	Ef - Erythroblastosis Foetalis
Erythroblastosis Fetalis	Haemolytic Disease Due To Rhesus Isoimmunisation
Rhesus Isoimmunisation Of The Newborn

Type 1 Diabetes Mellitus 12

Diabetes Mellitus, Insulin-Dependent, 12	IDDM12
Insulin-Dependent Diabetes Mellitus 12	T1D12
Type 1 Diabetes Mellitus 12, Susceptibility To	Diabetes Mellitus, Insulin-Dependent, Type 12

Andersen Cardiodysrhythmic Periodic Paralysis

Andersen Syndrome	Andersen-Tawil Syndrome
LQT7	Long Qt Syndrome 7
Ats	Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type
Long Qt Syndrome Type 7	Andersen Tawil Syndrome
Potassium-Sensitive Cardiodysrhythmic Type	Lqts Type 7
Long Qt Syndrome-7

Umbilical Hernia

Hernia, Umbilical

Hypokalemic Periodic Paralysis, Type 1

Hypokalemic Periodic Paralysis	Hokpp
Hypopp	Westphall Disease
HOKPP1	Familial Hypokalemic Periodic Paralysis
Familial Periodic Paralysis	Westphal Disease
Hypokalemic Periodic Paralysis Type 1	Hypokalemic Familial Periodic Paralysis
Periodic Hypokalemic Paralysis	Periodic Paralysis I
Hypokpp	Primary Hypokalemic Periodic Paralysis
Periodic Paralysis Hypokalemic 1	Paralysis, Hypokalemic, Periodic
Paralysis, Hypokalemic, Periodic, Type 1

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07138	KCNJ11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNJ11	VGNC	VGNC:42259
Mus musculus	KCNJ11	MGD	MGI:107501
Rattus norvegicus	KCNJ11	RGD	RGD:69247
Bos taurus	KCNJ11	VGNC	VGNC:30455
Felis catus	KCNJ11	VGNC	VGNC:67911