ARL4D - ADP ribosylation factor like GTPase 4D Gene

Homo sapiens

Also known as ARF4L

Gene ID: 379 | Gene type: protein coding

About ARL4D

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,398,993-43,401,137 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 30 paralogues. Broad expression in thyroid (RPKM 16.5), esophagus (RPKM 15.6) and 20 other tissues.

Summary

ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. [provided by RefSeq, Jul 2021]

ARL4D Products(1)

mRNA	Protein	Name
NM_001661.4	NP_001652.2	ADP-ribosylation factor-like protein 4D

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17398095	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17398095	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17398095	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 4D

ADP-ribosylation factor-like 4D

ARL4D Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARL4D	P49703	CCDC102B	Homo sapiens	Q68D86	Anti Tag CoIP	25416956
Intra	ARL4D	P49703	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	ARL4D	P49703	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bardet-Biedl Syndrome 3

BBS3	Bardet-Biedl Syndrome, Type 3

Noonan Syndrome 13

NS13

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00990	ARL4D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARL4D	VGNC	VGNC:70001
Canis familiaris	ARL4D	VGNC	VGNC:38114
Rattus norvegicus	ARL4D	RGD	RGD:1306875
Bos taurus	ARL4D	VGNC	VGNC:26146
Mus musculus	ARL4D	MGD	MGI:1933155

Name
Email *

	Sorry, but the email address you supplied was invalid.