ARF5 - ADP ribosylation factor 5 Gene

Homo sapiens

Gene ID: 381 | Gene type: protein coding

About ARF5

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:127,588,411-127,591,700 (from NCBI)

This gene has 6 transcripts (splice variants), 235 orthologues and 30 paralogues. Ubiquitous expression in esophagus (RPKM 84.6), skin (RPKM 63.4) and 25 other tissues.

Summary

This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of Phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the Ras superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]

ARF5 Products(1)

mRNA	Protein	Name
NM_001662.4	NP_001653.1	ADP-ribosylation factor 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17030804	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IGI IGI: Inferred from genetic interaction	24768165	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARF5 Protein Structure

Arf

0
100
180 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor 5

ARF5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARF5	P84085	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
Intra	ARF5	P84085	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	ARF5	P84085	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	ARF5	P84085	ACY3	Homo sapiens	Q96HD9	Validated Y2H	32296183
Intra	ARF5	P84085	ACY3	Homo sapiens	Q96HD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Geroderma Osteodysplasticum

Gerodermia Osteodysplastica	Geroderma Osteodysplastica
GO	Walt Disney Dwarfism
Type Of Gerodermia Osteodysplastica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00897	ARF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARF5	VGNC	VGNC:68041
Mus musculus	ARF5	MGD	MGI:99434
Macaca mulatta	ARF5	VGNC	VGNC:80792
Canis familiaris	ARF5	VGNC	VGNC:54754
Rattus norvegicus	ARF5	RGD	RGD:621278
Bos taurus	ARF5	VGNC	VGNC:26060
Others	ARF5	NCBI

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