DTX3 - deltex E3 ubiquitin ligase 3 Gene

Homo sapiens

Also known as RNF154; deltex3

Gene ID: 196403 | Gene type: protein coding

About DTX3

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,604,824-57,609,802 (from NCBI)

This gene has 9 transcripts (splice variants), 183 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 21.6), endometrium (RPKM 16.7) and 24 other tissues.

Summary

DTX3 functions as an E3 ubiquitin Ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

DTX3 Products(3)

mRNA	Protein	Name
NM_001286245.2	NP_001273174.1	probable E3 ubiquitin-protein ligase DTX3 isoform b
NM_001286246.2	NP_001273175.1	probable E3 ubiquitin-protein ligase DTX3 isoform a
NM_178502.4	NP_848597.1	probable E3 ubiquitin-protein ligase DTX3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19549727	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTX3 Protein Structure

zf-RING_2

0
100
200
300
347 a.a.

Protein Preferred Names

Protein Names

probable E3 ubiquitin-protein ligase DTX3

RING finger protein 154

DTX3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DTX3	Q8N9I9	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	FYN	Homo sapiens	P06241-3	MAPPIT	32296183
Intra	DTX3	Q8N9I9	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	PARP11	Homo sapiens	Q9NR21-1	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	UBE2L6	Homo sapiens	O14933	Y2H Array	19549727
Intra	DTX3	Q8N9I9	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	UBE2K	Homo sapiens	P61086	Validated Y2H	25416956
Intra	DTX3	Q8N9I9	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	DTX3	Q8N9I9	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	DTX3	Q8N9I9	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	DTX3	Q8N9I9	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	DTX3	Q8N9I9	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cutaneous Diphtheria

Diphtheria Wound Infection

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation	Intracranial Arteriovenous Malformation
Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To	Intracranial Arteriovenous Malformations
Bavm	Cerebral Arteriovenous Malformations
Intracranial Hemorrhage In Brain Cerebrovascular Malformations	Arteriovenous Malformation Of The Brain, Somatic
Intracranial Avm	Arteriovenous Malformations Cerebral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04040	DTX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04041	DTX3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DTX3	VGNC	VGNC:28238
Mus musculus	DTX3	MGD	MGI:2135752
Rattus norvegicus	DTX3	RGD	RGD:1566181
Canis familiaris	DTX3	VGNC	VGNC:40117
Macaca mulatta	DTX3	VGNC	VGNC:71896
Felis catus	DTX3	VGNC	VGNC:61650
Others	DTX3	NCBI

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