CENPW - centromere protein W Gene

Homo sapiens

Also known as CUG2; CENP-W; C6orf173

Gene ID: 387103 | Gene type: protein coding

About CENPW

Cytogenetic location: 6q22.32 Genomic coordinates (GRCh38): 6:126,340,115-126,483,320 (from NCBI)

This gene has 3 transcripts (splice variants) and 124 orthologues. Broad expression in bone marrow (RPKM 2.8), testis (RPKM 2.0) and 20 other tissues.

Summary

Predicted to enable DNA binding activity and protein heterodimerization activity. Involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Located in kinetochore and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CENPW Products(3)

mRNA	Protein	Name
NM_001012507.4	NP_001012525.1	centromere protein W isoform b
NM_001286524.2	NP_001273453.1	centromere protein W isoform a
NM_001286525.2	NP_001273454.1	centromere protein W isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19070575	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	21695110	GOA
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	21695110	GOA
involved in kinetochore assembly	IMP IMP: Inferred from mutant phenotype	21695110	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21695110	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	19533040	GOA
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	21695110	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPW Protein Structure

CENP-W

0
88 a.a.

Protein Preferred Names

Protein Names

centromere protein W

cancer-up-regulated gene 2 protein

CENPW Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CENPW	Q5EE01	CENPT	Homo sapiens	Q96BT3	Anti Tag CoIP	19533040
Intra	CENPW	Q5EE01	CENPT	Homo sapiens	Q96BT3	Anti Tag CoIP	33961781
Intra	CENPW	Q5EE01	CENPT	Homo sapiens	Q96BT3	Y2H	19533040
Intra	CENPW	Q5EE01	CENPT	Homo sapiens	Q96BT3	GMS	22304917
Intra	CENPW	Q5EE01	CENPT	Homo sapiens	Q96BT3	Pull Down	19533040

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Acromesomelic Dysplasia 2b

Fibular Hypoplasia And Complex Brachydactyly	Du Pan Syndrome
AMD2B	Dupans
Acromesomelic Dysplasia-2b	Fibular Aplasia-Complex Brachydactyly Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02494	CENPW Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CENPW	VGNC	VGNC:60763
Mus musculus	CENPW	MGD	MGI:1913561
Rattus norvegicus	CENPW	RGD	RGD:1593465
Canis familiaris	CENPW	VGNC	VGNC:39114
Bos taurus	CENPW	VGNC	VGNC:27187
Macaca mulatta	CENPW	VGNC	VGNC:71071

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