SCIMP - SLP adaptor and CSK interacting membrane protein Gene

Homo sapiens

Also known as UNQ5783; C17orf87

Gene ID: 388325 | Gene type: protein coding

About SCIMP

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,208,920-5,234,860 (from NCBI)

This gene has 4 transcripts (splice variants), 88 orthologues and 2 paralogues. Biased expression in spleen (RPKM 11.9), lymph node (RPKM 9.3) and 13 other tissues.

Summary

This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

SCIMP Products(3)

mRNA	Protein	Name
NM_001271842.1	NP_001258771.1	SLP adapter and CSK-interacting membrane protein isoform 2
NM_001319190.2	NP_001306119.1	SLP adapter and CSK-interacting membrane protein isoform 3
NM_207103.3	NP_996986.1	SLP adapter and CSK-interacting membrane protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21930792	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	21930792	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in immunological synapse	IDA IDA: Inferred from direct assay	21930792	GOA
located in leading edge membrane	IDA IDA: Inferred from direct assay	21930792	GOA
located in membrane	IDA IDA: Inferred from direct assay	21930792	GOA
located in tetraspanin-enriched microdomain	IDA IDA: Inferred from direct assay	21930792	GOA
located in uropod membrane	IDA IDA: Inferred from direct assay	21930792	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCIMP Protein Structure

SCIMP

0
100
145 a.a.

Protein Preferred Names

Protein Names

SLP adapter and CSK-interacting membrane protein

DTFT5783

SCIMP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCIMP	Q6UWF3	CSK	Homo sapiens	P41240	Anti Tag CoIP	21930792
Intra	SCIMP	Q6UWF3	CCDC81	Homo sapiens	Q6ZN84	Anti Tag CoIP	21930792
Intra	SCIMP	Q6UWF3	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SCIMP	Q6UWF3	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SCIMP	Q6UWF3	LYN	Homo sapiens	P07948	Anti Tag CoIP	21930792

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12511	SCIMP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SCIMP	VGNC	VGNC:99447
Canis familiaris	SCIMP	VGNC	VGNC:59032
Mus musculus	SCIMP	MGD	MGI:3610314
Rattus norvegicus	SCIMP	RGD	RGD:1593299
Bos taurus	SCIMP	VGNC	VGNC:34338
Macaca mulatta	SCIMP	VGNC	VGNC:77146

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