TRABD2B - TraB domain containing 2B Gene

Homo sapiens

Also known as TIKI2

Gene ID: 388630 | Gene type: protein coding

About TRABD2B

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,760,528-47,997,385 (from NCBI)

This gene has 2 transcripts (splice variants), 113 orthologues and 1 paralogue. Broad expression in kidney (RPKM 3.6), gall bladder (RPKM 0.8) and 16 other tissues.

Summary

Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Is integral component of organelle membrane and integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TRABD2B Products(1)

mRNA	Protein	Name
NM_001194986.2	NP_001181915.1	metalloprotease TIKI2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt-protein binding	IDA IDA: Inferred from direct assay	22726442	GOA
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	22726442	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	22726442	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22726442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	22726442	GOA
involved in positive regulation of protein oxidation	IDA IDA: Inferred from direct assay	22726442	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	22726442	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	22726442	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in organelle membrane	IDA IDA: Inferred from direct assay	22726442	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22726442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRABD2B Protein Structure

TraB

0
100
200
300
400
517 a.a.

Protein Preferred Names

Protein Names

metalloprotease TIKI2

TRAB domain-containing protein 2B

TRABD2B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	TRABD2B	A6NFA1	Wnt3a	Mus musculus	P27467	Anti Tag CoIP	22726442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14965	TRABD2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRABD2B	VGNC	VGNC:84867
Macaca mulatta	TRABD2B	VGNC	VGNC:100176
Mus musculus	TRABD2B	MGD	MGI:3650152
Bos taurus	TRABD2B	VGNC	VGNC:106996
Felis catus	TRABD2B	VGNC	VGNC:80391
Rattus norvegicus	TRABD2B	RGD	RGD:1586386

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