LAIR2 - leukocyte associated immunoglobulin like receptor 2 Gene

Homo sapiens

Also known as CD306

Gene ID: 3904 | Gene type: protein coding

About LAIR2

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,502,831-54,510,687 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 215 orthologues and 25 paralogues. Biased expression in placenta (RPKM 4.7), lymph node (RPKM 0.9) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

LAIR2 Products(2)

mRNA	Protein	Name
NM_002288.6	NP_002279.2	leukocyte-associated immunoglobulin-like receptor 2 isoform a precursor
NM_021270.5	NP_067154.1	leukocyte-associated immunoglobulin-like receptor 2 isoform b precursor

LAIR2 Protein Structure

Ig_2

0
100
152 a.a.

Protein Preferred Names

Protein Names

leukocyte-associated immunoglobulin-like receptor 2

LAIR-2

LAIR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LAIR2	Q6ISS4	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Prey Pooling	32296183
Intra	LAIR2	Q6ISS4	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Array	32296183
Intra	LAIR2	Q6ISS4	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	LAIR2	Q6ISS4	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	LAIR2	Q6ISS4	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	LAIR2	Q6ISS4	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	LAIR2	Q6ISS4	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	LAIR2	Q6ISS4	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	LAIR2	Q6ISS4	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	LAIR2	Q6ISS4	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	LAIR2	Q6ISS4	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	LAIR2	Q6ISS4	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	LAIR2	Q6ISS4	EMILIN1	Homo sapiens	Q9Y6C2	Validated Y2H	25416956
Intra	LAIR2	Q6ISS4	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	LAIR2	Q6ISS4	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	LAIR2	Q6ISS4	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LAIR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72391	LAIR2 Protein, Human (Biotinylated, HEK293, Avi-His)	Q6ISS4-1 (Q22-P152)	≥95%
HY-P72527	LAIR2 Protein, Human (HEK293, His)	Q6ISS4-1 (Q22-P152)	≥95%
HY-P77050	LAIR2 Protein, Human (HEK293)	Q6ISS4-1 (Q22-P152)	≥95%
HY-P78323	LAIR2 Protein, Human (HEK293, His-Avi)	Q6ISS4-1 (Q22-P152)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07495	LAIR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LAIR2	MGD	MGI:105492
Others	LAIR2	NCBI

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