ARHGAP5 - Rho GTPase activating protein 5 Gene

Homo sapiens

Also known as GFI2; p190-B; RhoGAP5; p190BRhoGAP

Gene ID: 394 | Gene type: protein coding

About ARHGAP5

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:32,075,880-32,159,728 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 87 phenotypes. Ubiquitous expression in thyroid (RPKM 21.1), brain (RPKM 17.8) and 25 other tissues.

Summary

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate Cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGAP5 Products(2)

mRNA	Protein	Name
NM_001030055.2	NP_001025226.1	rho GTPase-activating protein 5 isoform a
NM_001173.3	NP_001164.2	rho GTPase-activating protein 5 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	1689011	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23622247	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP5 Protein Structure

Ras

RhoGAP

0
300
600
900
1200
1502 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 5

growth factor independent 2

ARHGAP5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	ARHGAP5	Q13017	Rnd3	Mus musculus	P61588	Anti Tag CoIP	23622247

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00939	ARHGAP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARHGAP5	VGNC	VGNC:70008
Rattus norvegicus	ARHGAP5	RGD	RGD:1308507
Bos taurus	ARHGAP5	VGNC	VGNC:26098
Canis familiaris	ARHGAP5	VGNC	VGNC:38067
Felis catus	ARHGAP5	VGNC	VGNC:68119
Mus musculus	ARHGAP5	MGD	MGI:1332637

Name
Email *

	Sorry, but the email address you supplied was invalid.