LDHC - lactate dehydrogenase C Gene

Homo sapiens

Also known as CT32; LDH3; LDHX

Gene ID: 3948 | Gene type: protein coding

About LDHC

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,412,318-18,452,063 (from NCBI)

This gene has 10 transcripts (splice variants), 98 orthologues and 5 paralogues. Restricted expression toward testis (RPKM 186.5).

Summary

Lactate Dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the Lactate Dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]

LDHC Products(2)

mRNA	Protein	Name
NM_002301.5	NP_002292.1	L-lactate dehydrogenase C chain
NM_017448.5	NP_059144.1	L-lactate dehydrogenase C chain

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDHC Protein Structure

Ldh_1_N

Ldh_1_C

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

L-lactate dehydrogenase C chain

LDH testis subunit

LDHC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LDHC	P07864	LDHB	Homo sapiens	P07195	Anti Tag CoIP	33961781
Intra	LDHC	P07864	LDHA	Homo sapiens	P00338	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Varicocele

Scrotal Varices	Varicoceles
Varicocele Of Scrotum	Scrotal Varicocele

Korean Hemorrhagic Fever

Hemorrhagic Fever With Renal Syndrome

Nuclear Senile Cataract

Senile Nuclear Cataract

Senile Nuclear Sclerosis

Phototoxic Dermatitis

Dermatitis, Phototoxic	Photosensitisation Reaction
Photosensitive Dermatitis	Photosensitiveness

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07573	LDHC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LDHC	RGD	RGD:69366
Bos taurus	LDHC	VGNC	VGNC:56270
Mus musculus	LDHC	MGD	MGI:96764
Felis catus	LDHC	VGNC	VGNC:82036
Macaca mulatta	LDHC	VGNC	VGNC:74247
Canis familiaris	LDHC	VGNC	VGNC:52264
Others	LDHC	NCBI

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