MYO18A - myosin XVIIIA Gene

Homo sapiens

Also known as MAJN; TIAF1; MYSPDZ; SPR210; SP-R210

Gene ID: 399687 | Gene type: protein coding

About MYO18A

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:29,071,122-29,212,727 (from NCBI)

This gene has 25 transcripts (splice variants), 279 orthologues and 43 paralogues. Ubiquitous expression in skin (RPKM 21.0), bone marrow (RPKM 16.2) and 25 other tissues.

Summary

The protein encoded by this gene can bind GOLPH3, linking the Golgi to the Cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]

MYO18A Products(6)

mRNA	Protein	Name
NM_001346765.2	NP_001333694.1	unconventional myosin-XVIIIa isoform c
NM_001346766.2	NP_001333695.1	unconventional myosin-XVIIIa isoform d
NM_001346767.2	NP_001333696.1	unconventional myosin-XVIIIa isoform e
NM_001346768.2	NP_001333697.1	unconventional myosin-XVIIIa isoform f
NM_078471.4	NP_510880.2	unconventional myosin-XVIIIa isoform a
NM_203318.2	NP_976063.1	unconventional myosin-XVIIIa isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	23990465	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	23990465	GOA
NOT enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	23990465	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	23990465	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19837035	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	19837035	GOA
involved in Golgi ribbon formation	IMP IMP: Inferred from mutant phenotype	19837035	GOA
involved in Golgi vesicle budding	IMP IMP: Inferred from mutant phenotype	19837035	GOA
involved in actomyosin structure organization	IMP IMP: Inferred from mutant phenotype	18854160	GOA
involved in asymmetric Golgi ribbon formation	IMP IMP: Inferred from mutant phenotype	19837035	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18854160	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24485452	GOA
involved in positive regulation of opsonization	IMP IMP: Inferred from mutant phenotype	21123169	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	23345592	GOA
involved in regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	25965346	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actomyosin	IDA IDA: Inferred from direct assay	18854160	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	19837035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO18A Protein Structure

PDZ

Myosin_head

Myosin_tail_1

0
400
800
1200
1600
2054 a.a.

Protein Preferred Names

Protein Names

unconventional myosin-XVIIIa

12 kDa TGF-beta-1-induced antiapoptotic factor

Related Diseases

Diseases

Alias

Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia	Atypical Chronic Myeloid Leukaemia
Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative	Acml
Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative
Atypical Cml	Subacute Myeloid Leukemia
Subacute Myelogenous Leukaemia	Subacute Myeloid Leukaemia
Subacute Myelosis	Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission
Subacute Monocytic Leukaemia Without Mention Of Remission	Subacute Monocytic Leukaemia

Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder	Tic Disorders
Tic Disorder	Tic Disorder Nos
Tic Nos	Tic Spasm Nos

Alzheimer Disease 18

AD18	Alzheimer'S Disease 18
Alzheimer Disease 18, Late-Onset	Alzheimer Disease 18, Susceptibility To
Alzheimer'S Disease 18, Late Onset	Alzheimer Disease 18 Late-Onset
Alzheimer Disease, Susceptibility To, Type 18

Developmental And Epileptic Encephalopathy 28

DEE28	Epileptic Encephalopathy, Early Infantile, 28
Eiee28	Developmental And Epileptic Encephalopathy, 28
Early Infantile Epileptic Encephalopathy 28	Encephalopathy, Epileptic, Early Infantile, Type 28

Intellectual Developmental Disorder, Autosomal Dominant 22

MRD22	Mental Retardation, Autosomal Dominant 22
Autosomal Dominant Non-Syndromic Intellectual Disability 22	Distal Monosomy 1q
Autosomal Dominant Intellectual Developmental Disorder 22	Autosomal Dominant Mental Retardation 22
Distal Deletion 1q	Monosomy 1qter
Telomeric Deletion 1q	Mental Retardation, Autosomal Dominant, Type 22

Developmental And Epileptic Encephalopathy 65

DEE65	Epileptic Encephalopathy, Early Infantile, 65
Eiee65	Developmental And Epileptic Encephalopathy, 65
Early Infantile Epileptic Encephalopathy 65	Encephalopathy, Epileptic, Early Infantile, Type 65

Developmental And Epileptic Encephalopathy 84

DEE84	Jamuar Syndrome
Eiee84	Developmental And Epileptic Encephalopathy, 84
Epileptic Encephalopathy, Early Ifantile, 84	Early Infantile Epileptic Encephalopathy 84
Epileptic Encephalopathy, Early Infantile, 84	Encephalopathy, Epileptic, Early Infantile, Type 84

Infancy Electroclinical Syndrome

Myeloproliferative Neoplasm

Myeloproliferative Disorder	Chronic Myeloproliferative Disease
Myeloproliferative Neoplasms	Chronic Myeloproliferative Disorder
Cmpd	Cmpd, U
Chronic Myeloproliferative Disorders	Mpd
Mpn	Myeloproliferative Disorders
Myeloproliferative Disease	Campomelic Dysplasia

Spinocerebellar Ataxia, Autosomal Recessive 12

Autosomal Recessive Spinocerebellar Ataxia 12	SCAR12
Spinocerebellar Ataxia With Mental Retardation And Epilepsy	Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Wwox Deficiency
Autosomal Recessive Spinocerebellar Ataxia Type 12	Spinocerebellar Ataxia, Autosomal Recessive, 12
Ataxia, Spinocerebellar, Autosomal Recessive, Type 12

West Syndrome

Infantile Spasms	Infantile Spasms Syndrome
Infantile Spasm	X-Linked Infantile Spasm Syndrome
X-Linked Infantile Spasms	Epileptic Encephalopathy, Early Infantile, 1
Is	Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg
West'S Syndrome	Spasms, Infantile
Is -[Infantile Spasm]	Salaam Spasm
Salaam Tic

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Bardet-Biedl Syndrome 1

BBS1	Bardet-Biedl Syndrome 1, Modifier Of
Bardet-Biedl Syndrome	BBS
Bardet-Biedl Syndrome, Type 1	Laurence-Moon-Bardet-Biedl Syndrome

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08934	MYO18A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MYO18A	VGNC	VGNC:31813
Macaca mulatta	MYO18A	VGNC	VGNC:75058
Felis catus	MYO18A	VGNC	VGNC:63685
Mus musculus	MYO18A	MGD	MGI:2667185
Rattus norvegicus	MYO18A	RGD	RGD:1562698
Canis familiaris	MYO18A	VGNC	VGNC:43557

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