CD180 - CD180 molecule Gene

Homo sapiens

Also known as LY64; Ly78; RP105

Gene ID: 4064 | Gene type: protein coding

About CD180

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:67,179,613-67,196,799 (from NCBI)

This gene has 2 transcripts (splice variants), 128 orthologues and 22 paralogues. Biased expression in lymph node (RPKM 23.1), spleen (RPKM 12.8) and 10 other tissues.

Summary

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

CD180 Products(1)

mRNA	Protein	Name
NM_005582.3	NP_005573.2	CD180 antigen precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21857663	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	10880523	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD180 Protein Structure

LRR_8

0
200
400
600
661 a.a.

Protein Preferred Names

Protein Names

CD180 antigen

lymphocyte antigen 64

Recombinant CD180 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77181	RP105/CD180 Protein, Human (HEK293, His)	Q99467/NP_005573.2 (W24-G626)	≥95%

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 85

RP85	Retinitis Pigmentosa, Type 85

Ross River Fever

Ross River Virus Disease

Ross River Virus Infection

Retinitis Pigmentosa 74

RP74	Retinitis Pigmentosa, Type 74

Brachydactyly, Type C

Brachydactyly Type C	BDC
Brachydactyly Haws Type	Brachydactyly, Haws Type
Brachydactyly C

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02197	CD180 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CD180	VGNC	VGNC:102176
Mus musculus	CD180	MGD	MGI:1194924
Macaca mulatta	CD180	VGNC	VGNC:70929
Bos taurus	CD180	VGNC	VGNC:52748
Canis familiaris	CD180	VGNC	VGNC:52119
Rattus norvegicus	CD180	RGD	RGD:1308170
Others	CD180	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.