CAPRIN1 - cell cycle associated protein 1 Gene

Homo sapiens

Also known as M11S1; GPIAP1; RNG105; GPIP137; GRIP137; p137GPI

Gene ID: 4076 | Gene type: protein coding

About CAPRIN1

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,051,731-34,102,610 (from NCBI)

This gene has 17 transcripts (splice variants), 292 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 43.8), brain (RPKM 23.0) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in negative regulation of translation and positive regulation of dendritic spine morphogenesis. Located in cell leading edge and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CAPRIN1 Products(2)

mRNA	Protein	Name
NM_005898.5	NP_005889.3	caprin-1 isoform 1
NM_203364.3	NP_976240.1	caprin-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	34074792	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	17210633	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	31439799	GOA
enables molecular function activator activity	IDA IDA: Inferred from direct assay	32302570	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18005740	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	31439799	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	31439799	GOA
involved in non-membrane-bounded organelle assembly	IDA IDA: Inferred from direct assay	31439799	GOA
involved in positive regulation of stress granule assembly	IDA IDA: Inferred from direct assay	27022092	GOA
involved in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA IDA: Inferred from direct assay	31439799	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	28733330	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	28733330	GOA
is active in intracellular non-membrane-bounded organelle	IDA IDA: Inferred from direct assay	31439799	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPRIN1 Protein Structure

Caprin-1_C

0
200
400
600
709 a.a.

Protein Preferred Names

Protein Names

caprin-1

GPI-anchored membrane protein 1

CAPRIN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAPRIN1	Q14444	G3BP1	Homo sapiens	Q13283	Fluorescence	18005740
Intra	CAPRIN1	Q14444	G3BP1	Homo sapiens	Q13283	FPS	34799561

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Moyamoya Angiopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162288	FAZ-3532	Inhibitor	99.66%	Unkown
HY-162289	FAZ-3780		98.91%	Unkown
HY-161110	APP degrader-1	Degrader	98.35%	Unkown
HY-RS01897	CAPRIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-165042	1,2-Dipalmitoyl-3-decanoyl-rac-glycerol		/	Unkown
HY-165105	1,3-Dioleoyl-2-decanoyl glycerol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CAPRIN1	VGNC	VGNC:68117
Bos taurus	CAPRIN1	VGNC	VGNC:26751
Macaca mulatta	CAPRIN1	VGNC	VGNC:70692
Rattus norvegicus	CAPRIN1	RGD	RGD:1305707
Mus musculus	CAPRIN1	MGD	MGI:1858234
Canis familiaris	CAPRIN1	VGNC	VGNC:51857

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