G3BP1 - G3BP stress granule assembly factor 1 Gene

Homo sapiens

Also known as G3BP; HDH-VIII

Gene ID: 10146 | Gene type: protein coding

About G3BP1

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:151,771,954-151,812,785 (from NCBI)

This gene has 78 transcripts (splice variants), 238 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 18.3), appendix (RPKM 16.8) and 25 other tissues.

Summary

This gene encodes one of the DNA-unwinding Enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This Enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

G3BP1 Products(2)

mRNA	Protein	Name
NM_005754.3	NP_005745.1	ras GTPase-activating protein-binding protein 1
NM_198395.2	NP_938405.1	ras GTPase-activating protein-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA helicase activity	IDA IDA: Inferred from direct assay	9889278	GOA
enables DNA/RNA helicase activity	IDA IDA: Inferred from direct assay	9889278	GOA
enables RNA helicase activity	IDA IDA: Inferred from direct assay	9889278	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	32302570	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8649363	GOA
enables ribosomal small subunit binding	IDA IDA: Inferred from direct assay	27022092	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	30510222	GOA
involved in positive regulation of stress granule assembly	IMP IMP: Inferred from mutant phenotype	23279204	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	30804210	GOA
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	30510222	GOA
involved in stress granule assembly	IDA IDA: Inferred from direct assay	27022092	GOA
involved in stress granule assembly	IMP IMP: Inferred from mutant phenotype	20180778	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30510222	GOA
is active in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	32302570	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	30404792	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20180778	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

G3BP1 Protein Structure

NTF2

RRM_1

0
100
200
300
400
466 a.a.

Protein Preferred Names

Protein Names

ras GTPase-activating protein-binding protein 1

ATP-dependent DNA helicase VIII

G3BP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	G3BP1	Q13283	SND1	Homo sapiens	Q7KZF4	IF	20643132
Intra	G3BP1	Q13283	CAPRIN1	Homo sapiens	Q14444	Anti Tag CoIP	34799561
Intra	G3BP1	Q13283	CAPRIN1	Homo sapiens	Q14444	IF	34799561
Intra	G3BP1	Q13283	CAPRIN1	Homo sapiens	Q14444	Anti Tag CoIP	35271311
Intra	G3BP1	Q13283	CAPRIN1	Homo sapiens	Q14444	TAP	24981860
Intra	G3BP1	Q13283	CAPRIN1	Homo sapiens	Q14444	Anti Bait CoIP	34901782
Intra	G3BP1	Q13283	TRIM25	Homo sapiens	Q14258	FPS	34799561
Intra	G3BP1	Q13283	TRIM25	Homo sapiens	Q14258	Anti Tag CoIP	34799561
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	Y2H Prey Pooling	32296183
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	Anti Bait CoIP	34901782
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	Y2H Array	32296183
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	TAP	24981860
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	Anti Bait CoIP	33495715
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	Anti Bait CoIP	21455491
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	Validated Y2H	32296183
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	Anti Tag CoIP	35271311
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	FPS	34799561
Intra	G3BP1	Q13283	USP10	Homo sapiens	Q14694	Anti Tag CoIP	19615732
Cross	G3BP1	Q13283	N	SARS-CoV-2	P0DTC9	IF	34799561
Cross	G3BP1	Q13283	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34035218
Cross	G3BP1	Q13283	N	SARS-CoV-2	P0DTC9	Pull Down	34400613
Cross	G3BP1	Q13283	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34799561
Cross	G3BP1	Q13283	N	SARS-CoV-2	P0DTC9	ITC	34400613
Cross	G3BP1	Q13283	N	SARS-CoV-2	P0DTC9	Confocal	34035218
Cross	G3BP1	Q13283	N	SARS-CoV-2	P0DTC9	Confocal	34780058
Cross	G3BP1	Q13283	N	SARS-CoV-2	P0DTC9	FPS	34799561
Cross	G3BP1	Q13283	N	SARS-CoV-2	P0DTC9	Confocal	33495715
Cross	G3BP1	Q13283	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Anti Tag CoIP	35075101
Cross	G3BP1	Q13283	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Confocal	35075101
Cross	G3BP1	Q13283	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Anti Bait CoIP	35075101
Intra	G3BP1	Q13283	NSD1	Homo sapiens	Q96L73	Phage Display	39009827
Intra	G3BP1	Q13283	NSD1	Homo sapiens	Q96L73	FPS	39009827
Intra	G3BP1	Q13283	UBAP2L	Homo sapiens	Q14157	Anti Tag CoIP	34799561
Intra	G3BP1	Q13283	UBAP2L	Homo sapiens	Q14157	IF	34799561
Intra	G3BP1	Q13283	UBAP2L	Homo sapiens	Q14157	FPS	34799561
Intra	G3BP1	Q13283	ATXN2	Homo sapiens	Q99700	Anti Bait CoIP	23209657
Intra	G3BP1	Q13283	DDIT3	Homo sapiens	P35638	Anti Tag CoIP	34799561
Cross	G3BP1	Q13283	N	Human SARS coronavirus	P59595	Pull Down	34400613
Cross	G3BP1	Q13283	N	Human SARS coronavirus	P59595	P8 Filamentous Phage	34799561
Cross	G3BP1	Q13283	N	Human SARS coronavirus	P59595	Confocal	34035218
Cross	G3BP1	Q13283	N	Human SARS coronavirus	P59595	Phage Display	37100772
Cross	G3BP1	Q13283	N	Human SARS coronavirus	P59595	IF	34799561
Cross	G3BP1	Q13283	N	Human SARS coronavirus	P59595	Anti Tag CoIP	34035218
Cross	G3BP1	Q13283	N	Human SARS coronavirus	P59595	FPS	34799561
Intra	G3BP1	Q13283	ATXN2L	Homo sapiens	Q8WWM7	Anti Tag CoIP	19615732
Intra	G3BP1	Q13283	ATXN2L	Homo sapiens	Q8WWM7	TAP	24981860
Intra	G3BP1	Q13283	ATXN2L	Homo sapiens	Q8WWM7	Anti Bait CoIP	23209657
Cross	G3BP1	Q13283	N	Middle East respiratory syndrome-related coronavirus	K9N4V7	IF	34799561
Cross	G3BP1	Q13283	N	Middle East respiratory syndrome-related coronavirus	K9N4V7	Confocal	34035218
Cross	G3BP1	Q13283	N	Middle East respiratory syndrome-related coronavirus	K9N4V7	Pull Down	34400613

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Mouth Disease

Mouth Diseases

Mouth Disorders

Multisystem Proteinopathy

Epithelial-Stromal Tgfbi Dystrophy

Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162288	FAZ-3532		99.66%	Unkown
HY-162289	FAZ-3780		98.91%	Unkown
HY-RS05189	G3BP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	G3BP1	VGNC	VGNC:41038
Rattus norvegicus	G3BP1	RGD	RGD:621140
Mus musculus	G3BP1	MGD	MGI:1351465
Macaca mulatta	G3BP1	VGNC	VGNC:72810
Felis catus	G3BP1	VGNC	VGNC:97440
Bos taurus	G3BP1	VGNC	VGNC:29176
Others	G3BP1	NCBI

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