STS - steroid sulfatase Gene

Homo sapiens

Also known as ES; ASC; XLI; ARSC; SSDD; ARSC1

Gene ID: 412 | Gene type: protein coding

About STS

Cytogenetic location: Xp22.31 Genomic coordinates (GRCh38): X:7,147,290-7,354,641 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues, 16 paralogues and is associated with 4 phenotypes. Broad expression in placenta (RPKM 15.1), fat (RPKM 11.7) and 22 other tissues.

Summary

This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and Cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

STS Products(6)

mRNA	Protein	Name
NM_000351.7	NP_000342.3	steryl-sulfatase isoform 1 precursor
NM_001320750.3	NP_001307679.1	steryl-sulfatase isoform 2 precursor
NM_001320751.2	NP_001307680.1	steryl-sulfatase isoform 2 precursor
NM_001320752.2	NP_001307681.2	steryl-sulfatase isoform 1 precursor
NM_001320753.2	NP_001307682.1	steryl-sulfatase isoform 1 precursor
NM_001320754.2	NP_001307683.1	steryl-sulfatase isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sulfuric ester hydrolase activity	IDA IDA: Inferred from direct assay	15962010	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STS Protein Structure

Sulfatase

Sulfatase_C

0
100
200
300
400
500
583 a.a.

Protein Preferred Names

Protein Names

steryl-sulfatase

arylsulfatase C

Related Diseases

Diseases

Alias

Ichthyosis, X-Linked

X-Linked Ichthyosis	Steroid Sulfatase Deficiency
Placental Steroid Sulfatase Deficiency	Steroid Sulfatase Deficiency Disease
XLI	Sts Deficiency
Ssdd	X-Linked Recessive Ichthyosis
X-Linked Ichthyosis With Steryl-Sulphatase Deficiency	X-Linked Placental Steryl-Sulphatase Deficiency
Ssd	X Linked Ichthyosis
Recessive X-Linked Ichthyosis	Rxli
Syndromic Recessive X-Linked Ichthyosis	Recessive X-Linked Ichthyosis With Extracutaneous Manifestations
Syndromic Rxli	X-Linked Ichthyosis Syndrome
IXL	Ichthyosis X-Linked
Sex-Linked Ichthyosis	X-Linked Ichthyosis With Steryl-Sulfatase Deficiency

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Ichthyosis Vulgaris

Ichthyosis Simplex	Dominant Congenital Ichthyosiform Erythroderma
Common Ichthyosis	Fish Scale Disease
VI	Ichthyoses
Congenital Ichthyosis

Multiple Sulfatase Deficiency

Mucosulfatidosis	MSD
Sulfatidosis, Juvenile, Austin Type	Multiple Sulfatase Deficiency Disease
Juvenile Sulfatidosis, Austin Type	Juvenile Sulfatidosis
Sulfatidosis Juvenile, Austin Type	Austin Syndrome
Sulfatidosis Juvenile Austin Type	Sulfatase Deficiency, Multiple

Chondrodysplasia Punctata Syndrome

Chondrodysplasia Punctata	Chondrodysplasia Punctata Congenita
Toriello Higgins Miller Syndrome	Chondrodysplasia Punctata, Toriello Type
Toriello-Higgins-Miller Syndrome	Cdp
Chondrodysplasia Punctata, X-Linked Dominant Type	Chondrodysplasia Punctata Group
Dysplasia Punctata Epiphysis	Dysplasia Punctata
Dysplasia Epiphysealis Punctata	Chondrodystrophy Of Punctata

Smith-Lemli-Opitz Syndrome

SLOS	Rsh Syndrome
7-Dehydrocholesterol Reductase Deficiency	Slo Syndrome
Rutledge Lethal Multiple Congenital Anomaly Syndrome	Lethal Acrodysgenital Syndrome
Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung	Smith-Opitz-Inborn Syndrome
Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung	Smith Lemli Opitz Syndrome
Smith-Lemli-Opitz Syndrome, Type Ii

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Chondrodysplasia Punctata 2, X-Linked Dominant

CDPX2	Happle Syndrome
Chondrodysplasia Punctata, X-Linked Dominant	Cdpxd
Cpxd	Conradi-Hunermann Syndrome
Conradi-Hunermann-Happle Syndrome	Chondrodysplasia Punctata 2 X-Linked Dominant
X-Linked Dominant Chondrodysplasia Punctata 2	Conrad Hunermann Happle Syndrome
Conradi Hunermann Syndrome	Chh
Chondrodysplasia Punctata, Type 2, X-Linked Dominant	Chondrodysplasia Punctata, X-Linked Dominant Type
Chondrodysplasia Punctata

Metachromatic Leukodystrophy

Arylsulfatase A Deficiency	MLD
Arsa Deficiency	Sulfatide Lipidosis
Metachromatic Leukoencephalopathy	Cerebral Sclerosis, Diffuse, Metachromatic Form
Cerebroside Sulfatase Deficiency	Leukodystrophy, Metachromatic
Pseudoarylsulfatase A Deficiency	Leukodystrophy Metachromatic
Sulfatidosis	Metachromatic Leukodystrophy, Late Infantile
Metachromatic Leukodystrophy Variant	Deficiency Of Cerebroside-Sulfatase
Scholz Cerebral Sclerosis	Sulfatide Lipoidosis
Cerebral Sclerosis Diffuse Metachromatic Form	Arylsulfatase A Deficiency Disease
Cerebroside Sulphatase Deficiency Disease	Greenfield Disease
Metachromatic Leukodystrophy, Adult	Metachromatic Leukodystrophy, Juvenile
Leukodystrophy Metachromatic Adult	Leukodystrophy Metachromatic Juvenile
Leukodystrophy Metachromatic Late Infantile	Metachromatic Leukodystrophy, Adult Type
Metachromatic Leukodystrophy, Juvenile Type	Metachromatic Leukodystrophy, Infant
Greenfield'S Disease

Ocular Albinism

Albinism, Ocular	Oa
Xloa	Albinism Ocular

Alopecia, Androgenetic, 1

Androgenetic Alopecia	Androgenic Alopecia
AGA1	Aga
Female Pattern Baldness	Male Pattern Alopecia
Male Pattern Baldness	Pattern Baldness
Alopecia, Androgenetic	Alopecia Androgenetic
Female Pattern Alopecia

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma	Bullous Ichthyosiform Erythroderma
EHK	Bullous Erythroderma Ichthyosiformis Congenita Of Brocq
Bcie	Bie
Epidermolytic Ichthyosis	Ichthyosis Bullosa Of Siemens
Superficial Epidermolytic Ichthyosis	Hyperkeratosis, Epidermolytic
Congenital Bullous Ichthyosiform Erythroderma	Bullous Type Ichthyosis
Epidermolytic Palmoplantar Hyperkeratosis	Bullous Ichthyosiform Erythroderma Congenita
Bullous Erythroderma Ichthyosiforme	Sei
Epidermolytic Hyperkeratosis Late-Onset	Epidermolytic Hyperkeratosis, Late-Onset

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Corneal Dystrophy, Thiel-Behnke Type

Thiel-Behnke Corneal Dystrophy	Tbcd
CDTB	Cdb2
Corneal Dystrophy Of Bowman Layer Type Ii	Anterior Limiting Membrane Dystrophy Type Ii
Waardenburg-Jonker Corneal Dystrophy	Corneal Dystrophy Of Bowman Layer, Type Ii
Corneal Dystrophy, Honeycomb-Shaped	Corneal Dystrophy Honeycomb-Shaped
Corneal Dystrophy Thiel Behnke Type	Corneal Dystrophy Honeycomb Shaped
Corneal Dystrophy Of The Bowman Layer Type 2	Thiel Behnke Corneal Dystrophy
Anterior Limiting Membrane Dystrophy Type 2	Corneal Dystrophy Of Bowman Layer Type 2
Curly Fiber Corneal Dystrophy	Honeycomb Corneal Dystrophy
Honeycomb-Shaped Corneal Dystrophy	Dystrophy, Corneal, Thiel-Behnke Type

Dysostosis

Dysostoses

Cri-Du-Chat Syndrome

5p Deletion Syndrome	5p Partial Monosomy Syndrome
Monosomy 5p	Cat Cry Syndrome
Chromosome 5p Deletion Syndrome	Cri Du Chat Syndrome
5p- Syndrome	5p Minus Syndrome
Chromosome 5p- Syndrome	Chromosome 5 Short Arm Deletion Syndrome
Chromosome 5p Deletion	Deletion 5p
Cri Du Chat	5p Partial Deletion Syndrome
Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113293B	Estrone sulfate sodium		99.84%	Unkown
HY-B0084	Dienogest	Agonist	99.90%	Unkown

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15141	Staurosporine		99.98%	Unkown
HY-113293BS1	Estrone sulfate-d4 sodium		99.38%	Unkown
HY-W062700	STS-E412		99.72%	Unkown
HY-14585	Estrone O-sulfamate	Inhibitor	99.99%	Unkown
HY-15141G	Staurosporine (GMP)	Inhibitor	/	Unkown
HY-113293BS	Estrone sulfate-d5 sodium		/	Unkown
HY-150542	Steroid sulfatase-IN-2	Inhibitor	/	Unkown
HY-150543	Steroid sulfatase-IN-3	Inhibitor	/	Unkown
HY-151200	Steroid sulfatase-IN-4	Inhibitor	/	Unkown
HY-151201	Steroid sulfatase/17β-HSD1-IN-3	Inhibitor	/	Unkown
HY-151202	Steroid sulfatase/17β-HSD1-IN-4	Inhibitor	/	Unkown
HY-155010	Steroid sulfatase/17β-HSD1-IN-5	Inhibitor	/	Unkown
HY-155233	Steroid sulfatase-IN-5	Inhibitor	/	Unkown
HY-155234	Steroid sulfatase-IN-6	Inhibitor	/	Unkown
HY-155235	Steroid sulfatase-IN-7	Inhibitor	/	Unkown
HY-156511	ETC-168	Inhibitor	/	Unkown
HY-156902	Steroid sulfatase-IN-8	Inhibitor	/	Unkown
HY-B0084S	Dienogest-d4		/	Unkown
HY-B0084S1	Dienogest-d5		/	Unkown
HY-B0084S2	Dienogest-d6		/	Unkown
HY-B0084S4	Dienogest-13C,15N,d4	Agonist	/	Unkown
HY-RS13969	STS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-B0084S3	Dienogest-13C2,15N	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STS	RGD	RGD:3783
Canis familiaris	STS	VGNC	VGNC:54604
Felis catus	STS	VGNC	VGNC:97650
Bos taurus	STS	VGNC	VGNC:49976
Macaca mulatta	STS	VGNC	VGNC:81590
Mus musculus	STS	MGD	MGI:98438
Others	STS	NCBI

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