DNAJB9 - DnaJ heat shock protein family (Hsp40) member B9 Gene

Homo sapiens

Also known as MDG1; ERdj4; MDG-1; MST049; MSTP049

Gene ID: 4189 | Gene type: protein coding

About DNAJB9

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:108,569,874-108,574,850 (from NCBI)

This gene has 3 transcripts (splice variants), 268 orthologues and 11 paralogues. Ubiquitous expression in thyroid (RPKM 55.6), adrenal (RPKM 35.9) and 25 other tissues.

Summary

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from Apoptosis. [provided by RefSeq, Dec 2010]

DNAJB9 Products(1)

mRNA	Protein	Name
NM_012328.3	NP_036460.1	dnaJ homolog subfamily B member 9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables misfolded protein binding	IDA IDA: Inferred from direct assay	18400946	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19815549	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	18400946	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB9 Protein Structure

DnaJ

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily B member 9

DnaJ (Hsp40) homolog, subfamily B, member 9

DNAJB9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNAJB9	Q9UBS3	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunoglobulin Heavy Chain Amyloidosis

Ah Amyloidosis	Heavy Chain Amyloidosis
Amyloidosis Derived From Immunoglobulin Heavy Chain	Ig Heavy-Chain-Associated Amyloidosis

Gestational Ovarian Choriocarcinoma

Non-Gestational Choriocarcinoma

Choriocarcinoma, Non-Gestational

Non-Gestational Ovarian Choriocarcinoma

Choriocarcinoma Of Ovary

Ovarian Choriocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03871	DNAJB9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DNAJB9	VGNC	VGNC:108396
Felis catus	DNAJB9	VGNC	VGNC:80595
Rattus norvegicus	DNAJB9	RGD	RGD:3070
Canis familiaris	DNAJB9	VGNC	VGNC:53539
Mus musculus	DNAJB9	MGD	MGI:1351618

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