MEST - mesoderm specific transcript Gene

Homo sapiens

Also known as PEG1

Gene ID: 4232 | Gene type: protein coding

About MEST

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,486,175-130,506,465 (from NCBI)

This gene has 17 transcripts (splice variants), 242 orthologues and 12 paralogues. Biased expression in placenta (RPKM 292.2), fat (RPKM 48.4) and 6 other tissues.

Summary

This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of Cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

MEST Products(6)

mRNA	Protein	Name
NM_001253900.1	NP_001240829.1	mesoderm-specific transcript homolog protein isoform c
NM_001253901.1	NP_001240830.1	mesoderm-specific transcript homolog protein isoform d precursor
NM_001253902.1	NP_001240831.1	mesoderm-specific transcript homolog protein isoform d precursor
NM_002402.4	NP_002393.2	mesoderm-specific transcript homolog protein isoform a
NM_177524.2	NP_803490.1	mesoderm-specific transcript homolog protein isoform b precursor
NM_177525.2	NP_803491.1	mesoderm-specific transcript homolog protein isoform b precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEST Protein Structure

Abhydrolase_6

0
100
200
300
335 a.a.

Protein Preferred Names

Protein Names

mesoderm-specific transcript homolog protein

paternally-expressed gene 1 protein

Related Diseases

Diseases

Alias

Childhood-Onset Schizophrenia

Childhood Schizophrenia

Schizophrenia, Childhood

Adult Cystic Nephroma

Multilocular Cystic Nephroma, Mixed Epithelial Stromal Tumour And Renal Epithelial Stromal Tumour

Mixed Epithelial Stromal Tumour

Kidney Cortex Disease

Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal	Tndm
Chromosome 6-Associated Transient Diabetes Mellitus	Dmtn
Diabetes Mellitus, 6q24-Related Transient Neonatal	Tndm1
Neonatal Diabetes Mellitus, Transient	Tndm -[Transient Neonatal Diabetes Mellitus]

Mulchandani-Bhoj-Conlin Syndrome

MBCS	Maternal Uniparental Disomy Of Chromosome 20
Maternal Upd(20)	Upd(20)Mat
Uniparental Disomy, Maternal, Chromosome 20

Hypersensitivity Vasculitis

Cutaneous Small Vessel Vasculitis	Hypersensitivity Angiitis
Cutaneous Leukocytoclastic Vasculitis	Leukocytoclastic Angiitis
Vasculitis, Leukocytoclastic, Cutaneous	Leukocytoclastic Vasculitis
Cutaneous Leukocytoclastic Angiitis	Cutaneous Hypersensitivity Vasculitis
Vasculitis Hypersensitivity	Drug Induced Cutaneous Vasculitis
Allergic Vasculitis

Silver-Russell Syndrome 1

Silver-Russell Syndrome	Russell-Silver Syndrome
Silver-Russell Dwarfism	Rss
SRS1	Srs
Silver Russell Dwarfism	Russell Silver Syndrome
Silver Russell Syndrome

Henoch-Schoenlein Purpura

Henoch-Schonlein Purpura	Iga Vasculitis
Allergic Purpura	Anaphylactoid Purpura
Rheumatoid Purpura	Immunoglobulin A Vasculitis
Vascular Purpura	Purpura Rheumatica
Henoch-Schönlein Purpura	Autoimmune Purpura
Henoch-Schnlein Purpura	Henoch-Sch@Nlein Purpura
Henoch-Scholein Purpura	Purpura, Autoimmune
Henoch Schonlein Purpura	Immunoglobulin-A Vasculitis
Purpura, Schonlein-Henoch	Purpura, Schönlein-Henoch
Hsp -	Schönlein-Henoch Purpura

Hypersensitivity Reaction Type Iii Disease

Immune Complex Diseases	Immune Complex Disease
Type Iii Hypersensitivity Reaction Disease

Rapidly Progressive Glomerulonephritis

Glomerulonephritis Rapidly Progressive

Idiopathic Crescentic Glomerulonephritis

Temple Syndrome

Uniparental Disomy, Maternal, Chromosome 14	Temple Syndrome Due To Paternal 14q32.2 Microdeletion
Paternal Del(14)(Q32.2)	Temple Syndrome Due To Paternal 14q32.2 Hypomethylation
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14	Upd(14)Mat

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Spastic Paraplegia 17, Autosomal Dominant

Silver Syndrome	SPG17
Silver Spastic Paraplegia Syndrome	Spastic Paraplegia With Amyotrophy Of Hands And Feet
Hereditary Spastic Paraplegia 17	Autosomal Dominant Spastic Paraplegia Type 17
Spastic Paraplegia 17	Spastic Paraplegia-Amyotrophy Of Hands And Feet
Autosomal Dominant Spastic Paraplegia 17	Dhmn5b
Distal Hereditary Motor Neuropathy Type 5b	Paraplegia, Spastic, Autosomal Dominant, Type 17
Russell-Silver Syndrome	Neuronopathy, Distal Hereditary Motor, Type Vb

Iga Glomerulonephritis

Iga Nephropathy	Glomerulonephritis, Iga
Berger'S Iga Or Igg Nephropathy	Focal Glomerulonephritis
Primary Iga Nephropathy	Segmental Glomerulonephritis
Berger Disease	Berger'S Disease
Igan	Nephritis, Iga Type
Nephropathy Iga	Glomerulonephritis Focal
Iga Nephropathy, Susceptibility To	Primary Immunoglobulin A Nephropathy

Kagami-Ogata Syndrome

Paternal Uniparental Disomy Of Chromosome 14	Uniparental Disomy, Paternal, Chromosome 14
Kos	Mca Due To 14q32.2 Maternally Expressed Gene Defect
Paternal Uniparental Disomy 14	Kagami-Ogata Syndrome Due To Maternal 14q32.2 Microdeletion
Maternal Del(14)(Q32.2)	Maternal Monosomy 14q32.2
Kagami-Ogata Syndrome Due To Maternal 14q32.2 Hypermethylation	Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Upd(14)Pat

Pseudohypoparathyroidism, Type Ib

Pseudohypoparathyroidism Type 1b	PHP1B
Pseudohypoparathyroidism Ib	Pseudohypoparathyroidism Type Ib
Php Ib	Pseudohypoparathyroidism 1b

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Adult Syndrome

Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome	Acro Dermato Ungual Lacrimal Tooth Syndrome
Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome	Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome
Adult

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14336A	SB 271046 Hydrochloride	Antagonist	99.93%	Unkown
HY-RS08344	MEST Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MEST	VGNC	VGNC:43165
Macaca mulatta	MEST	VGNC	VGNC:74707
Rattus norvegicus	MEST	RGD	RGD:1594589
Mus musculus	MEST	MGD	MGI:96968
Bos taurus	MEST	VGNC	VGNC:31393
Felis catus	MEST	VGNC	VGNC:97504
Macaca fascicularis	MEST	NCBI	NCBI:102137842
Others	MEST	NCBI

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