2. Gene
  3. RNF19B - ring finger protein 19B Gene

RNF19B - ring finger protein 19B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NKLAM; IBRDC3

Gene ID: 127544 | Gene type: protein coding

About RNF19B

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,929,036-32,964,809 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 9 paralogues. Broad expression in testis (RPKM 31.7), bone marrow (RPKM 15.6) and 23 other tissues.

Summary

This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein Ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]

RNF19B Products(3)

mRNA Protein Name
NM_001127361.3 NP_001120833.1 E3 ubiquitin-protein ligase RNF19B isoform b
NM_001300826.2 NP_001287755.1 E3 ubiquitin-protein ligase RNF19B isoform c
NM_153341.4 NP_699172.2 E3 ubiquitin-protein ligase RNF19B isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16709802 GOA
enables ubiquitin binding IDA
IDA: Inferred from direct assay
27485036 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
27485036 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
27485036 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
27485036 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF19B Protein Structure

IBR

IBR: IBR domain, a half RING-finger domain (187 - 251)

IBR

IBR: IBR domain, a half RING-finger domain (282 - 326)

  • 0
  • 200
  • 400
  • 600
  • 732 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF19B

IBR domain-containing protein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12073 RNF19B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RNF19B VGNC VGNC:80344
Mus musculus RNF19B MGD MGI:1922484
Bos taurus RNF19B VGNC VGNC:34045
Rattus norvegicus RNF19B RGD RGD:1305470
Macaca mulatta RNF19B VGNC VGNC:106488
Canis familiaris RNF19B VGNC VGNC:45651