MNAT1 - MNAT1 component of CDK activating kinase Gene

Homo sapiens

Also known as MAT1; TFB3; CAP35; RNF66

Gene ID: 4331 | Gene type: protein coding

About MNAT1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:60,734,761-60,969,965 (from NCBI)

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in fat (RPKM 3.3), prostate (RPKM 3.0) and 25 other tissues.

Summary

The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

MNAT1 Products(2)

mRNA	Protein	Name
NM_001177963.2	NP_001171434.1	CDK-activating kinase assembly factor MAT1 isoform 2
NM_002431.4	NP_002422.1	CDK-activating kinase assembly factor MAT1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8692842	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	23622515	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9852112	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8692842	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	8692841	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CAK-ERCC2 complex	IDA IDA: Inferred from direct assay	8692841	GOA
part of cyclin-dependent protein kinase holoenzyme complex	IDA IDA: Inferred from direct assay	23622515	GOA
part of transcription factor TFIIH core complex	IDA IDA: Inferred from direct assay	8692841	GOA
part of transcription factor TFIIH holo complex	IDA IDA: Inferred from direct assay	9852112	GOA
part of transcription factor TFIIK complex	IDA IDA: Inferred from direct assay	8692841	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MNAT1 Protein Structure

MAT1

0
100
200
309 a.a.

Protein Preferred Names

Protein Names

CDK-activating kinase assembly factor MAT1

CDK7/cyclin-H assembly factor

MNAT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MNAT1	P51948	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	MNAT1	P51948	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	MNAT1	P51948	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	MNAT1	P51948	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	MNAT1	P51948	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	MNAT1	P51948	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	MNAT1	P51948	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	26871637
Intra	MNAT1	P51948	GOLGA2	Homo sapiens	Q08379	Validated Y2H	26871637
Intra	MNAT1	P51948	GOLGA2	Homo sapiens	Q08379	Y2H Array	26871637

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MNAT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75361	CDK7-CCNH-MNAT1 Protein, Human (sf9, His)	P50613 (A2-F346)&P51946 (Y2-L323)&P51948 (D2-S309)	≥95%

Related Diseases

Diseases

Alias

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Seckel Syndrome 2

SCKL2	Seckel-Type Dwarfism 2
Microcephalic Primordial Dwarfism 2	Bird-Headed Dwarfism 2
Seckel Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08566	MNAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MNAT1	VGNC	VGNC:43295
Bos taurus	MNAT1	VGNC	VGNC:31537
Rattus norvegicus	MNAT1	RGD	RGD:628874
Felis catus	MNAT1	VGNC	VGNC:68295
Mus musculus	MNAT1	MGD	MGI:106207
Macaca mulatta	MNAT1	VGNC	VGNC:74905
Others	MNAT1	NCBI

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