2. Gene
  3. RNF11 - ring finger protein 11 Gene

RNF11 - ring finger protein 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CGI-123; SID1669

Gene ID: 26994 | Gene type: protein coding

About RNF11

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:51,236,273-51,273,447 (from NCBI)

This gene has 3 transcripts (splice variants), 260 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 55.4) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]

RNF11 Products(1)

mRNA Protein Name
NM_014372.5 NP_055187.1 RING finger protein 11
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14755250 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
24105792 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
24105792 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
14755250 GOA
Cellular Component GO Annotation Evidence Reference Source
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
14755250 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF11 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (98 - 139)

  • 0
  • 100
  • 154 a.a.
Protein Preferred Names Protein Names

RING finger protein 11

RNF11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RNF11 Q9Y3C5 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32814053
Intra RNF11 Q9Y3C5 IQUB Homo sapiens Q8NA54
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 IQUB Homo sapiens Q8NA54
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 IQUB Homo sapiens Q8NA54
Y2H Array
32814053
Intra RNF11 Q9Y3C5 ATG10 Homo sapiens Q9H0Y0
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 ATG10 Homo sapiens Q9H0Y0
Y2H Array
32814053
Intra RNF11 Q9Y3C5 ATG10 Homo sapiens Q9H0Y0
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 UBE2V1 Homo sapiens Q13404
Enzymatic Study
19549727
Intra RNF11 Q9Y3C5 UBE2N Homo sapiens P61088
Y2H Array
19549727
Intra RNF11 Q9Y3C5 UBE2N Homo sapiens P61088
Enzymatic Study
19549727
Intra RNF11 Q9Y3C5 USP2 Homo sapiens O75604-3
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 USP2 Homo sapiens O75604-3
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 USP2 Homo sapiens O75604-3
Y2H Array
32814053
Intra RNF11 Q9Y3C5 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32814053
Intra RNF11 Q9Y3C5 WWOX Homo sapiens Q9NZC7-5
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 CLIP3 Homo sapiens Q96DZ5
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 CLIP3 Homo sapiens Q96DZ5
Y2H Array
32814053
Intra RNF11 Q9Y3C5 CLIP3 Homo sapiens Q96DZ5
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 PLEKHG7 Homo sapiens Q6ZR37
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 ITCH Homo sapiens Q96J02
Pull Down
20676133
Intra RNF11 Q9Y3C5 IL16 Homo sapiens Q14005-2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 IL16 Homo sapiens Q14005-2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 IL16 Homo sapiens Q14005-2
Y2H Array
32814053
Intra RNF11 Q9Y3C5 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 TRIM35 Homo sapiens Q9UPQ4-2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Array
32814053
Intra RNF11 Q9Y3C5 TCEAL8 Homo sapiens Q8IYN2
Y2H Array
32814053
Intra RNF11 Q9Y3C5 TCEAL8 Homo sapiens Q8IYN2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 TCEAL8 Homo sapiens Q8IYN2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 RNF14 Homo sapiens Q9UBS8
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 RNF14 Homo sapiens Q9UBS8
Y2H Array
32814053
Intra RNF11 Q9Y3C5 RNF14 Homo sapiens Q9UBS8
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 MPND Homo sapiens Q8N594
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 MPND Homo sapiens Q8N594
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 MPND Homo sapiens Q8N594
Y2H Array
32814053
Intra RNF11 Q9Y3C5 ANXA8 Homo sapiens P13928
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 ANXA8 Homo sapiens P13928
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 ANXA8 Homo sapiens P13928
Y2H Array
32814053
Intra RNF11 Q9Y3C5 OTUD7B Homo sapiens Q6GQQ9-2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 OTUD7B Homo sapiens Q6GQQ9-2
Y2H Array
32814053
Intra RNF11 Q9Y3C5 OTUD7B Homo sapiens Q6GQQ9-2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 TMEM61 Homo sapiens Q8N0U2
Y2H Array
32814053
Intra RNF11 Q9Y3C5 TMEM61 Homo sapiens Q8N0U2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 TMEM61 Homo sapiens Q8N0U2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 TMUB2 Homo sapiens Q71RG4-4
Y2H Array
32814053
Intra RNF11 Q9Y3C5 TMUB2 Homo sapiens Q71RG4-4
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 TMUB2 Homo sapiens Q71RG4-4
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 CNST Homo sapiens Q6PJW8-3
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 CNST Homo sapiens Q6PJW8-3
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 CNST Homo sapiens Q6PJW8-3
Y2H Array
32814053
Intra RNF11 Q9Y3C5 DKFZp547K2416 Homo sapiens Q8NDP9
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 DKFZp547K2416 Homo sapiens Q8NDP9
Y2H Array
32814053
Intra RNF11 Q9Y3C5 DKFZp547K2416 Homo sapiens Q8NDP9
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 ARNT2 Homo sapiens Q86TN1
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 ARNT2 Homo sapiens Q86TN1
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 ARNT2 Homo sapiens Q86TN1
Y2H Array
32814053
Intra RNF11 Q9Y3C5 CAMKK1 Homo sapiens Q8N5S9-2
Y2H Array
32814053
Intra RNF11 Q9Y3C5 CAMKK1 Homo sapiens Q8N5S9-2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 CAMKK1 Homo sapiens Q8N5S9-2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 KLF15 Homo sapiens Q9UIH9
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 KLF15 Homo sapiens Q9UIH9
Y2H Array
32814053
Intra RNF11 Q9Y3C5 KLF15 Homo sapiens Q9UIH9
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 HK3 Homo sapiens P52790
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 HK3 Homo sapiens P52790
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 HK3 Homo sapiens P52790
Y2H Array
32814053
Intra RNF11 Q9Y3C5 QARS1 Homo sapiens P47897
Y2H
15231748
Intra RNF11 Q9Y3C5 UBE2D2 Homo sapiens P62837
Y2H Array
19549727
Intra RNF11 Q9Y3C5 UBE2D2 Homo sapiens P62837
Y2H
15231748
Intra RNF11 Q9Y3C5 UBE2D2 Homo sapiens P62837
Y2H Array
19690564
Intra RNF11 Q9Y3C5 UBE2D2 Homo sapiens P62837
Y2H
19549727
Intra RNF11 Q9Y3C5 UBE2D3 Homo sapiens P61077
Y2H Array
19690564
Intra RNF11 Q9Y3C5 TDG Homo sapiens Q13569
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 TDG Homo sapiens Q13569
Y2H Array
32814053
Intra RNF11 Q9Y3C5 TDG Homo sapiens Q13569
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 UBE2E3 Homo sapiens Q969T4
Y2H Array
19549727
Intra RNF11 Q9Y3C5 UBA52 Homo sapiens P62987
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 UBA52 Homo sapiens P62987
Y2H
15231748
Intra RNF11 Q9Y3C5 UBA52 Homo sapiens P62987
Y2H Array
32814053
Intra RNF11 Q9Y3C5 UBA52 Homo sapiens P62987
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 RPS27A Homo sapiens P62979
Y2H
14755250
Intra RNF11 Q9Y3C5 PSMB8 Homo sapiens P28062-2
Y2H Array
32814053
Intra RNF11 Q9Y3C5 PSMB8 Homo sapiens P28062-2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 PSMB8 Homo sapiens P28062-2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 SMURF2 Homo sapiens Q9HAU4
Anti Tag CoIP
14755250
Intra RNF11 Q9Y3C5 SMURF2 Homo sapiens Q9HAU4
Pull Down
20676133
Intra RNF11 Q9Y3C5 UBB Homo sapiens P0CG47
Anti Tag CoIP
28514442
Intra RNF11 Q9Y3C5 UBB Homo sapiens P0CG47
Anti Tag CoIP
33961781
Intra RNF11 Q9Y3C5 UBB Homo sapiens P0CG47
Y2H
14755250
Intra RNF11 Q9Y3C5 GGA1 Homo sapiens Q9UJY5
Pull Down
20676133
Intra RNF11 Q9Y3C5 BAK1 Homo sapiens Q16611
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 BAK1 Homo sapiens Q16611
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 BAK1 Homo sapiens Q16611
Y2H Array
32814053
Intra RNF11 Q9Y3C5 TNFAIP3 Homo sapiens P21580
Anti Tag CoIP
19131965
Intra RNF11 Q9Y3C5 LPIN1 Homo sapiens Q14693
Y2H Array
32814053
Intra RNF11 Q9Y3C5 LPIN1 Homo sapiens Q14693
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 LPIN1 Homo sapiens Q14693
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 TAX1BP1 Homo sapiens Q86VP1
Anti Tag CoIP
19131965
Intra RNF11 Q9Y3C5 TAX1BP1 Homo sapiens Q86VP1
Y2H
15231748
Intra RNF11 Q9Y3C5 ASB13 Homo sapiens Q8WXK3
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 ASB13 Homo sapiens Q8WXK3
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 ASB13 Homo sapiens Q8WXK3
Y2H Array
32814053
Intra RNF11 Q9Y3C5 KLHL20 Homo sapiens Q9Y2M5
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 KLHL20 Homo sapiens Q9Y2M5
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 KLHL20 Homo sapiens Q9Y2M5
Y2H Array
32814053
Intra RNF11 Q9Y3C5 NGEF Homo sapiens Q8N5V2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 NGEF Homo sapiens Q8N5V2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 NGEF Homo sapiens Q8N5V2
Y2H Array
32814053
Intra RNF11 Q9Y3C5 NEDD4 Homo sapiens P46934
Pull Down
20676133
Intra RNF11 Q9Y3C5 NEDD4 Homo sapiens P46934
Y2H
15231748
Intra RNF11 Q9Y3C5 LNX1 Homo sapiens Q8TBB1
Y2H Array
32814053
Intra RNF11 Q9Y3C5 LNX1 Homo sapiens Q8TBB1
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 UBE2D1 Homo sapiens P51668
Y2H Array
19690564
Intra RNF11 Q9Y3C5 WWP2 Homo sapiens O00308
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 WWP2 Homo sapiens O00308
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 WWP2 Homo sapiens O00308
Y2H Array
32814053
Intra RNF11 Q9Y3C5 ILF3 Homo sapiens Q9NXX0
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 ILF3 Homo sapiens Q9NXX0
Y2H Array
32814053
Intra RNF11 Q9Y3C5 ILF3 Homo sapiens Q9NXX0
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 FOSL1 Homo sapiens P15407
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 FOSL1 Homo sapiens P15407
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 FOSL1 Homo sapiens P15407
Y2H Array
32814053
Intra RNF11 Q9Y3C5 UBE2D4 Homo sapiens Q9Y2X8
Y2H
15231748
Intra RNF11 Q9Y3C5 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
19549727
Intra RNF11 Q9Y3C5 UBE2D4 Homo sapiens Q9Y2X8
Y2H
21516116
Intra RNF11 Q9Y3C5 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
19690564
Intra RNF11 Q9Y3C5 TASOR2 Homo sapiens Q5VWN6
Y2H Array
32814053
Intra RNF11 Q9Y3C5 TASOR2 Homo sapiens Q5VWN6
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 TASOR2 Homo sapiens Q5VWN6
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 RAI2 Homo sapiens Q9Y5P3
Y2H Array
32814053
Intra RNF11 Q9Y3C5 RAI2 Homo sapiens Q9Y5P3
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 RAI2 Homo sapiens Q9Y5P3
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 LOXL4 Homo sapiens Q96JB6
Y2H Array
32814053
Intra RNF11 Q9Y3C5 LOXL4 Homo sapiens Q96JB6
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 LOXL4 Homo sapiens Q96JB6
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 SPPL2B Homo sapiens Q8TCT7-2
Y2H Array
32814053
Intra RNF11 Q9Y3C5 SPPL2B Homo sapiens Q8TCT7-2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 SPPL2B Homo sapiens Q8TCT7-2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 METTL27 Homo sapiens Q8N6F8
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 METTL27 Homo sapiens Q8N6F8
Y2H Array
32814053
Intra RNF11 Q9Y3C5 ZNF57 Homo sapiens Q68EA5
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 ZNF57 Homo sapiens Q68EA5
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 ZNF57 Homo sapiens Q68EA5
Y2H Array
32814053
Intra RNF11 Q9Y3C5 SEMA4G Homo sapiens Q9NTN9-3
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 SEMA4G Homo sapiens Q9NTN9-3
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 SEMA4G Homo sapiens Q9NTN9-3
Y2H Array
32814053
Intra RNF11 Q9Y3C5 RNF168 Homo sapiens Q8IYW5
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 RNF168 Homo sapiens Q8IYW5
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 RNF168 Homo sapiens Q8IYW5
Y2H Array
32814053
Intra RNF11 Q9Y3C5 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 UBQLN2 Homo sapiens Q9UHD9
Y2H
15231748
Intra RNF11 Q9Y3C5 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32814053
Intra RNF11 Q9Y3C5 UBQLN2 Homo sapiens Q9UHD9
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 BECN1 Homo sapiens Q14457
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 BECN1 Homo sapiens Q14457
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 BECN1 Homo sapiens Q14457
Y2H Array
32814053
Intra RNF11 Q9Y3C5 SMURF1 Homo sapiens Q9HCE7-2
Validated Y2H
32814053
Intra RNF11 Q9Y3C5 SMURF1 Homo sapiens Q9HCE7-2
Y2H Pooling
32814053
Intra RNF11 Q9Y3C5 SMURF1 Homo sapiens Q9HCE7-2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12035 RNF11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RNF11 VGNC VGNC:34009
Macaca mulatta RNF11 VGNC VGNC:76703
Felis catus RNF11 VGNC VGNC:80342
Mus musculus RNF11 MGD MGI:1352759
Rattus norvegicus RNF11 RGD RGD:2321596
Canis familiaris RNF11 VGNC VGNC:45620
Others RNF11 NCBI