CD200 - CD200 molecule Gene

Homo sapiens

Also known as MRC; MOX1; MOX2; OX-2

Gene ID: 4345 | Gene type: protein coding

About CD200

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,332,573-112,362,812 (from NCBI)

This gene has 8 transcripts (splice variants), 512 orthologues and 14 paralogues. Broad expression in brain (RPKM 5.4), placenta (RPKM 3.5) and 22 other tissues.

Summary

This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CD200 Products(10)

mRNA	Protein	Name
NM_001004196.4	NP_001004196.2	OX-2 membrane glycoprotein isoform b
NM_001318826.2	NP_001305755.1	OX-2 membrane glycoprotein isoform c
NM_001318828.2	NP_001305757.1	OX-2 membrane glycoprotein isoform d
NM_001318830.2	NP_001305759.1	OX-2 membrane glycoprotein isoform c
NM_001365851.2	NP_001352780.1	OX-2 membrane glycoprotein isoform e precursor
NM_001365852.1	NP_001352781.1	OX-2 membrane glycoprotein isoform f precursor
NM_001365853.1	NP_001352782.1	OX-2 membrane glycoprotein isoform f precursor
NM_001365854.1	NP_001352783.1	OX-2 membrane glycoprotein isoform f precursor
NM_001365855.1	NP_001352784.1	OX-2 membrane glycoprotein isoform c
NM_005944.7	NP_005935.4	OX-2 membrane glycoprotein isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in heterotypic cell-cell adhesion	IGI IGI: Inferred from genetic interaction	11260322	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	26670206	GOA
involved in negative regulation of matrix metallopeptidase secretion	IDA IDA: Inferred from direct assay	29101312	GOA
involved in positive regulation of CREB transcription factor activity	IDA IDA: Inferred from direct assay	26670206	GOA
involved in positive regulation of arginase activity	IGI IGI: Inferred from genetic interaction	26670206	GOA
involved in positive regulation of protein-glutamine gamma-glutamyltransferase activity	IGI IGI: Inferred from genetic interaction	26670206	GOA
involved in positive regulation of transforming growth factor beta production	IGI IGI: Inferred from genetic interaction	26670206	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	19151626	GOA
located in cell body	IDA IDA: Inferred from direct assay	19151626	GOA
located in cell surface	IDA IDA: Inferred from direct assay	11260322	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	19151626	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD200 Protein Structure

0
100
200
294 a.a.

Protein Preferred Names

Protein Names

OX-2 membrane glycoprotein

CD200 antigen

Recombinant CD200 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70476	CD200 Protein, Human (HEK293, His)	P41217-1 (Q31-G232)	≥95%
HY-P72887	CD200 Protein, Human (HEK293, Fc)	P41217-1 (Q31-G232)	≥95%
HY-P75432	CD200 Protein, Human (HEK293, Fc-Avi)	P41217-1/NP_005935.4 (Q31-G232)	≥95%

Related Diseases

Diseases

Alias

Inflamed Seborrheic Keratosis

Hairy Cell Leukemia

Hcl-V	Hairy Cell Leukemia Variant
Hairy Cell Leukaemia Variant	Hcl
Leukemic Reticuloendotheliosis	Leukemic Reticuloendotheliosis Variant
Prolymphocytic Variant Of Hcl	Prolymphocytic Variant Of Hairy Cell Leukemia
Leukemia Hairy Cell	Leukemia, Hairy Cell
Leukaemic Reticuloendotheliosis	Lre - [Leukemic Reticuloendotheliosis]
Hairy-Cell Leukaemia, Nos	Hcl - [Hairy Cell Leukaemia]
Hairy-Cell Leukaemia Without Mention Of Remission

B-Cell Prolymphocytic Leukemia

B Cell Prolymphocytic Leukemia	Prolymphocytic Leukemia, B-Cell Type
B-Pll	Doid:0081041
Leukemia, Prolymphocytic, B-Cell	Pll- [Prolymphocytic Leukaemia]
Prolymphocytic Leukaemia	Prolymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

Spiradenoma

Eccrine Spiradenoma	Benign Eccrine Spiradenoma
Eccrine Spiradenoma Of Skin	Es
Eccrine Spiradenoma, Benign

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Cll/Sll	B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Icdo:9823/3	Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Small Cell B-Cell Lymphoma

Androgenic Alopecia

Androgenetic Alopecia

Alopecia Androgenetica, Male Pattern Baldness

Methemoglobinemia And Ambiguous Genitalia

METAG	Methemoglobinemia Type Iv
Isolated 17,20-Lyase Deficiency, Pure	Methemoglobinemia Due To Deficiency Of Cytochrome B5
Methemoglobinemia Type 4	Methemoglobinemia Type Iv, Formerly
Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly	Pure Isolated 17,20-Lyase Deficiency
Methemoglobinemia, Type Iv

Rocky Mountain Spotted Fever

Brazillian Spotted	Choix
Exanthematic Typhus Of Sao Paulo	Fiebre Maculosa
Fiebre Manchada	Sao Paulo Typhus
So Paulo Fever	Tick Typhus
Tobia Fever	Rmsf
Typhus, Tick

Atrial Septal Defect 8

ASD8	Atrial Heart Septal Defect 8
Septal Defect, Atrial, Type 8

Flying Phobia

Aerophobia

Combined Oxidative Phosphorylation Deficiency 33

COXPD33

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Aniridia 1

Aniridia	Congenital Aniridia
AN1	An
Cataract With Late-Onset Corneal Dystrophy	Aplasia Of Iris
Absent Iris	Irideremia
Aniridia Ii, Formerly	An2, Formerly
An2	Aniridia Type Ii
Aniridia, Type 1	An-1
Absence Of Iris	Agenesis Of Iris
Congenital Absence Of Iris	Hereditary Aniridia
Sporadic Aniridia

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02205	CD200 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02206	CD200R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02207	CD200R1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD200	VGNC	VGNC:38938
Felis catus	CD200	VGNC	VGNC:102623
Rattus norvegicus	CD200	RGD	RGD:3104
Bos taurus	CD200	VGNC	VGNC:27010
Macaca mulatta	CD200	VGNC	VGNC:70931
Mus musculus	CD200	MGD	MGI:1196990
Macaca fascicularis	CD200	NCBI	NCBI:102146004
Others	CD200	NCBI

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