MZT1 - mitotic spindle organizing protein 1 Gene

Homo sapiens

Also known as MOZART1; C13orf37

Gene ID: 440145 | Gene type: protein coding

About MZT1

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:72,708,367-72,727,629 (from NCBI)

This gene has 1 transcript (splice variant) and 209 orthologues. Ubiquitous expression in brain (RPKM 11.3), bone marrow (RPKM 9.3) and 25 other tissues.

Summary

Involved in gamma-tubulin complex localization. Located in centrosome and spindle. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]

MZT1 Products(1)

mRNA	Protein	Name
NM_001071775.3	NP_001065243.1	mitotic-spindle organizing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20360068	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in gamma-tubulin complex localization	IMP IMP: Inferred from mutant phenotype	20360068	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	20360068	GOA
part of gamma-tubulin ring complex	IDA IDA: Inferred from direct assay	20360068	GOA
located in spindle	IDA IDA: Inferred from direct assay	20360068	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MZT1 Protein Structure

MOZART1

0
82 a.a.

Protein Preferred Names

Protein Names

mitotic-spindle organizing protein 1

mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1

MZT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MZT1	Q08AG7	TRIM72	Homo sapiens	Q6ZMU5	Validated Y2H	32296183
Intra	MZT1	Q08AG7	TUBG1	Homo sapiens	P23258	Anti Tag CoIP	33961781
Intra	MZT1	Q08AG7	TUBG1	Homo sapiens	P23258	Anti Tag CoIP	26496610
Intra	MZT1	Q08AG7	TUBG1	Homo sapiens	P23258	Anti Tag CoIP	28514442
Intra	MZT1	Q08AG7	TUBG1	Homo sapiens	P23258	TAP	20360068
Intra	MZT1	Q08AG7	TUBG1	Homo sapiens	P23258	Density Sedimentation	20360068
Intra	MZT1	Q08AG7	CYGB	Homo sapiens	Q8WWM9	Validated Y2H	32296183
Intra	MZT1	Q08AG7	CINP	Homo sapiens	Q9BW66	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Macular Degeneration, Age-Related, 2

Age Related Macular Degeneration 2	ARMD2
Macular Degeneration, Senile	Maculopathy, Age-Related, 2
Macular Degeneration, Age-Related, 2, Susceptibility To	Macular Degeneration, Age-Related, Type 2

Omodysplasia 1

OMOD1	Autosomal Recessive Omodysplasia
Omodysplasia Autosomal Recessive	Omodysplasia Generalized Form
Omodysplasia Type 1	Omodysplasia, Generalized Form
Omodysplasia, Autosomal Recessive	Micromelic Dysplasia, Congenital, With Dislocation Of Radius
Micromelic Dysplasia Congenita With Dislocation Of Radius	Micromelic Dysplasia-Dislocation Of Radius Syndrome
Micromelic Dysplasia Congenital With Dislocation Of Radius	Omodysplasia, Type 1

Abcd Syndrome

ABCDS	Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness
Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08977	MZT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MZT1	VGNC	VGNC:31851
Rattus norvegicus	MZT1	RGD	RGD:1592140
Macaca mulatta	MZT1	VGNC	VGNC:106274
Felis catus	MZT1	VGNC	VGNC:102260
Canis familiaris	MZT1	VGNC	VGNC:43595
Mus musculus	MZT1	MGD	MGI:1924039

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