TRIM72 - tripartite motif containing 72 Gene

Homo sapiens

Also known as MG53

Gene ID: 493829 | Gene type: protein coding

About TRIM72

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,214,119-31,231,537 (from NCBI)

This gene has 2 transcripts (splice variants), 104 orthologues and 80 paralogues. Biased expression in prostate (RPKM 2.0), esophagus (RPKM 0.3) and 1 other tissue.

Summary

Enables identical protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; plasma membrane repair; and protein homooligomerization. Predicted to act upstream of or within negative regulation of Insulin Receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; and negative regulation of myotube differentiation. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in cytoplasm and sarcolemma. [provided by Alliance of Genome Resources, Apr 2022]

TRIM72 Products(1)

mRNA	Protein	Name
NM_001008274.4	NP_001008275.2	tripartite motif-containing protein 72

TRIM72 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
477 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 72

mitsugumin-53

TRIM72 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM72	Q6ZMU5	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	TRIM72	Q6ZMU5	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	TRIM72	Q6ZMU5	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	TRIM72	Q6ZMU5	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	TRIM72	Q6ZMU5	PPP3CA	Homo sapiens	Q08209-2	Y2H Array	32296183
Intra	TRIM72	Q6ZMU5	PPP3CA	Homo sapiens	Q08209-2	Y2H Prey Pooling	32296183
Intra	TRIM72	Q6ZMU5	NMI	Homo sapiens	Q13287	Y2H Array	32296183
Intra	TRIM72	Q6ZMU5	MZT1	Homo sapiens	Q08AG7	Y2H Prey Pooling	32296183
Intra	TRIM72	Q6ZMU5	MED21	Homo sapiens	Q13503	Y2H Prey Pooling	32296183
Intra	TRIM72	Q6ZMU5	TCF12	Homo sapiens	Q99081	Y2H Prey Pooling	25416956
Intra	TRIM72	Q6ZMU5	MZT1	Homo sapiens	Q08AG7	Y2H Array	32296183
Intra	TRIM72	Q6ZMU5	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	TRIM72	Q6ZMU5	TCF12	Homo sapiens	Q99081	Y2H Array	25416956
Intra	TRIM72	Q6ZMU5	NMI	Homo sapiens	Q13287	Y2H Prey Pooling	32296183
Intra	TRIM72	Q6ZMU5	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	TRIM72	Q6ZMU5	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	TRIM72	Q6ZMU5	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	TRIM72	Q6ZMU5	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Miyoshi Muscular Dystrophy

Distal Myopathy	Distal Muscular Dystrophy
Miyoshi Myopathy	Distal Myopathies
Dystrophy, Muscular, Miyoshi	Myopathy, Distal
Distal Muscular Dystrophies

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

Lgmd2b	Lgmd3
Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency	Limb-Girdle Muscular Dystrophy Type 3
Muscular Dystrophy, Limb-Girdle, Type 2b

Glycogen Storage Disease Vii

Glycogen Storage Disease Type Vii	Muscle Phosphofructokinase Deficiency
Tarui Disease	GSD7
Pfkm Deficiency	Gsd Vii
Glycogen Storage Disease, Type Vii	Glycogen Storage Disease Type 7
Phosphofructokinase Deficiency	Glycogenosis Type Vii
Phosphofructokinase Myopathy	Glycogenosis 7
Glycogen Storage Disease Due To Muscle Phosphofructokinase Deficiency	Gsd Due To Muscle Phosphofructokinase Deficiency
Gsd Type 7	Gsd Type Vii
Glycogenosis Due To Muscle Phosphofructokinase Deficiency	Glycogenosis Type 7
Glycogen Storage Disease 7	Gsd-Vii
Storage Disease, Glycogen, Type Vii

Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Limb-Girdle Muscular Dystrophy

Lgmd	Limb Girdle Muscular Dystrophy
Muscular Dystrophies, Limb-Girdle	Erb'S Muscular Dystrophy
Leyden-Mbius Muscular Dystrophy	Limb-Girdle Syndrome
Myopathic Limb-Girdle Syndrome	Limb Girdle
Muscular Dystrophy Limb-Girdle	Dystrophy, Muscular, Limb-Girdle
Lgmd - [Limb-Girdle Muscular Dystrophy]	Limb Girdle Muscle Dystrophy
Limb-Girdle Myopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15071	TRIM72 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIM72	MGD	MGI:3612190
Canis familiaris	TRIM72	VGNC	VGNC:47838
Rattus norvegicus	TRIM72	RGD	RGD:1562778
Macaca mulatta	TRIM72	VGNC	VGNC:79927
Bos taurus	TRIM72	VGNC	VGNC:58423
Felis catus	TRIM72	VGNC	VGNC:66554
Others	TRIM72	NCBI

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