BECN2 - beclin 2 Gene

Homo sapiens

Also known as BECN1L1; BECN1P1

Gene ID: 441925 | Gene type: protein coding

About BECN2

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:241,957,767-241,959,062 (from NCBI)

This gene has 1 transcript (splice variant), 173 orthologues and 1 paralogue.

Summary

Acts upstream of or within G protein-coupled receptor catabolic process; autophagy; and endosome to lysosome transport. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. [provided by Alliance of Genome Resources, Apr 2022]

BECN2 Products(1)

mRNA	Protein	Name
NM_001290693.1	NP_001277622.1	beclin-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23954414	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor catabolic process	IMP IMP: Inferred from mutant phenotype	23954414	GOA
acts upstream of or within G protein-coupled receptor catabolic process	IPI IPI: Inferred from physical interaction	23954414	GOA
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	23954414	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	23954414	GOA
acts upstream of or within endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	23954414	GOA
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	23954414	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beclin-2

Beclin-1-like protein 1

BECN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BECN2	A8MW95	GPRASP1	Homo sapiens	Q5JY77	Anti Tag CoIP	23954414
Intra	BECN2	A8MW95	GPRASP1	Homo sapiens	Q5JY77	Y2H	23954414
Intra	BECN2	A8MW95	GPRASP1	Homo sapiens	Q5JY77	Anti Bait CoIP	23954414

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01466	BECN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BECN2	VGNC	VGNC:26464
Mus musculus	BECN2	MGD	MGI:2684950
Macaca mulatta	BECN2	VGNC	VGNC:106323
Rattus norvegicus	BECN2	RGD	RGD:1563293
Canis familiaris	BECN2	VGNC	VGNC:38428

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