GPRASP1 - G protein-coupled receptor associated sorting protein 1 Gene

Homo sapiens

Also known as GASP; GASP1; GASP-1

Gene ID: 9737 | Gene type: protein coding

About GPRASP1

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:102,651,483-102,659,083 (from NCBI)

This gene has 6 transcripts (splice variants), 126 orthologues and 11 paralogues. Broad expression in brain (RPKM 27.6), ovary (RPKM 20.3) and 21 other tissues.

Summary

This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 Dopamine Receptor (DRD2), delta Opioid Receptor (OPRD1), beta-2 Adrenergic Receptor (ADRB2), D4 Dopamine Receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]

GPRASP1 Products(4)

mRNA	Protein	Name
NM_001099410.2	NP_001092880.1	G-protein coupled receptor-associated sorting protein 1
NM_001099411.2	NP_001092881.1	G-protein coupled receptor-associated sorting protein 1
NM_001184727.2	NP_001171656.1	G-protein coupled receptor-associated sorting protein 1
NM_014710.5	NP_055525.3	G-protein coupled receptor-associated sorting protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15086532	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor catabolic process	IMP IMP: Inferred from mutant phenotype	23954414	GOA
acts upstream of or within G protein-coupled receptor catabolic process	IPI IPI: Inferred from physical interaction	23954414	GOA
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	23954414	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPRASP1 Protein Structure

Arm_2

0
300
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900
1200
1395 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor-associated sorting protein 1

GPRASP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPRASP1	Q5JY77	OPRD1	Homo sapiens	P41143	Y2H	15086532
Intra	GPRASP1	Q5JY77	OPRD1	Homo sapiens	P41143	Pull Down	15086532
Intra	GPRASP1	Q5JY77	BECN2	Homo sapiens	A8MW95	Anti Tag CoIP	23954414

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05747	GPRASP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GPRASP1	RGD	RGD:621343
Mus musculus	GPRASP1	MGD	MGI:1917418
Canis familiaris	GPRASP1	VGNC	VGNC:49803

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