2. Gene
  3. MSI1 - musashi RNA binding protein 1 Gene

MSI1 - musashi RNA binding protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 4440 | Gene type: protein coding

About MSI1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,339,662-120,369,164 (from NCBI)

This gene has 3 transcripts (splice variants), 286 orthologues, 36 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 2.5), brain (RPKM 2.0) and 14 other tissues.

Summary

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

MSI1 Products(15)

mRNA Protein Name
NM_001414485.1 NP_001401414.1 RNA-binding protein Musashi homolog 1 isoform b
NM_001414486.1 NP_001401415.1 RNA-binding protein Musashi homolog 1 isoform c
NM_001414487.1 NP_001401416.1 RNA-binding protein Musashi homolog 1 isoform d
NM_001414488.1 NP_001401417.1 RNA-binding protein Musashi homolog 1 isoform e
NM_001414489.1 NP_001401418.1 RNA-binding protein Musashi homolog 1 isoform f
NM_001414490.1 NP_001401419.1 RNA-binding protein Musashi homolog 1 isoform g
NM_001414491.1 NP_001401420.1 RNA-binding protein Musashi homolog 1 isoform h
NM_001414492.1 NP_001401421.1 RNA-binding protein Musashi homolog 1 isoform i
NM_001414493.1 NP_001401422.1 RNA-binding protein Musashi homolog 1 isoform j
NM_001414494.1 NP_001401423.1 RNA-binding protein Musashi homolog 1 isoform j
NM_001414495.1 NP_001401424.1 RNA-binding protein Musashi homolog 1 isoform j
NM_001414496.1 NP_001401425.1 RNA-binding protein Musashi homolog 1 isoform k
NM_001414497.1 NP_001401426.1 RNA-binding protein Musashi homolog 1 isoform l
NM_001414498.1 NP_001401427.1 RNA-binding protein Musashi homolog 1 isoform l
NM_002442.4 NP_002433.1 RNA-binding protein Musashi homolog 1 isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
30367664 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30367664 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSI1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (23 - 90)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (111 - 177)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

RNA-binding protein Musashi homolog 1

musashi-1

Related Diseases

Diseases Alias
Omsk Hemorrhagic Fever

Ohf

Hemorrhagic Fever, Omsk

Ohf - [Omsk Haemorrhagic Fever]

Spring-Fall Haemorrhagic Fever
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119734 Gossypolone / Unkown
HY-RS08714 MSI1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MSI1 VGNC VGNC:68325
Bos taurus MSI1 VGNC VGNC:31697
Macaca mulatta MSI1 VGNC VGNC:74935
Rattus norvegicus MSI1 RGD RGD:628778
Mus musculus MSI1 MGD MGI:107376
Canis familiaris MSI1 VGNC VGNC:43442