MST1 - macrophage stimulating 1 Gene

Homo sapiens

Also known as MSP; HGFL; NF15S2; D3F15S2; DNF15S2

Gene ID: 4485 | Gene type: protein coding

About MST1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,683,947-49,689,474 (from NCBI)

This gene has 21 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 45.2), duodenum (RPKM 24.6) and 13 other tissues.

Summary

The protein encoded by this gene contains four kringle domains and a serine Protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine Protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]

MST1 Products(6)

mRNA	Protein	Name
NM_001393581.1	NP_001380510.1	hepatocyte growth factor-like protein isoform 2 precursor
NM_001393582.1	NP_001380511.1	hepatocyte growth factor-like protein isoform 3 precursor
NM_001393583.1	NP_001380512.1	hepatocyte growth factor-like protein isoform 4 precursor
NM_001393584.1	NP_001380513.1	hepatocyte growth factor-like protein isoform 5 precursor
NM_001393585.1	NP_001380514.1	hepatocyte growth factor-like protein isoform 6 precursor
NM_020998.4	NP_066278.3	hepatocyte growth factor-like protein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22087277	GOA
enables receptor tyrosine kinase binding	IDA IDA: Inferred from direct assay	22087277	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	19720831	GOA
involved in regulation of cAMP-dependent protein kinase activity	IDA IDA: Inferred from direct assay	19720831	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7508914	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte growth factor-like protein

hepatocyte growth factor-like protein homolog

Related Diseases

Diseases

Alias

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Inflammatory Bowel Disease 12

IBD12

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15514	Merestinib	Inhibitor	99.99%	Phase 2
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100526	XMU-MP-1	Inhibitor	99.24%	Unkown
HY-128206	I3MT-3	Inhibitor	99.98%	Unkown
HY-151257	IHMT-MST1-58	Inhibitor	99.05%	Unkown
HY-164595	IHMT-MST1-39		/	Unkown
HY-P1790	Axltide		/	Unkown
HY-RS08729	MST1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08730	MST1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MST1	VGNC	VGNC:81281
Felis catus	MST1	VGNC	VGNC:80630
Mus musculus	MST1	MGD	MGI:96080
Rattus norvegicus	MST1	RGD	RGD:3114
Others	MST1	NCBI

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