MT1M - metallothionein 1M Gene

Homo sapiens

Also known as MT1; MT1K; MT-1M; MT-IM

Gene ID: 4499 | Gene type: protein coding

About MT1M

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,632,659-56,633,981 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 11 paralogues. Broad expression in colon (RPKM 54.9), small intestine (RPKM 40.3) and 14 other tissues.

Summary

This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]

MT1M Products(1)

mRNA	Protein	Name
NM_176870.3	NP_789846.2	metallothionein-1M

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT1M Protein Structure

Metallothio

0
61 a.a.

Protein Preferred Names

Protein Names

metallothionein-1M

metallothionein 1K

MT1M Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MT1M	Q8N339	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	MT1M	Q8N339	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	MT1M	Q8N339	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	MT1M	Q8N339	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Array	32296183
Intra	MT1M	Q8N339	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Prey Pooling	32296183
Intra	MT1M	Q8N339	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	MT1M	Q8N339	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	MT1M	Q8N339	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	MT1M	Q8N339	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	MT1M	Q8N339	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	MT1M	Q8N339	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	MT1M	Q8N339	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	MT1M	Q8N339	SMCP	Homo sapiens	P49901	Y2H Array	32296183
Intra	MT1M	Q8N339	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08741	MT1M Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MT1M	MGD	MGI:97171

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