MT1X - metallothionein 1X Gene

Homo sapiens

Also known as MT1; MT-1l

Gene ID: 4501 | Gene type: protein coding

About MT1X

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,682,470-56,684,196 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues and 11 paralogues. Broad expression in liver (RPKM 301.6), kidney (RPKM 245.8) and 16 other tissues.

Summary

Predicted to enable copper ion binding activity and zinc ion binding activity. Involved in cellular response to cadmium ion; cellular response to erythropoietin; and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MT1X Products(1)

mRNA	Protein	Name
NM_005952.4	NP_005943.1	metallothionein-1X

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	16827180	GOA
involved in cellular response to erythropoietin	IEP IEP: Inferred from expression pattern	11168427	GOA
involved in cellular response to zinc ion	IEP IEP: Inferred from expression pattern	11168427	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8619255	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8619255	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT1X Protein Structure

Metallothio

0
61 a.a.

Protein Preferred Names

Protein Names

metallothionein-1X

MT-1X

MT1X Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MT1X	P80297	SIX6OS1	Homo sapiens	Q8N1H7	Y2H Prey Pooling	32296183
Intra	MT1X	P80297	SIX6OS1	Homo sapiens	Q8N1H7	Validated Y2H	32296183
Intra	MT1X	P80297	SIX6OS1	Homo sapiens	Q8N1H7	Y2H Array	32296183
Intra	MT1X	P80297	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	MT1X	P80297	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08742	MT1X Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MT1X	MGD	MGI:97171

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