MVD - mevalonate diphosphate decarboxylase Gene

Homo sapiens

Also known as MPD; MDDase; POROK7; FP17780

Gene ID: 4597 | Gene type: protein coding

About MVD

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:88,651,940-88,663,091 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 12.6), duodenum (RPKM 12.3) and 25 other tissues.

Summary

The Enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in Cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]

MVD Products(1)

mRNA	Protein	Name
NM_002461.3	NP_002452.1	diphosphomevalonate decarboxylase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	12646231	GOA
enables diphosphomevalonate decarboxylase activity	IDA IDA: Inferred from direct assay	11792727	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	8626466	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in isoprenoid biosynthetic process	IDA IDA: Inferred from direct assay	11792727	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9270019	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	14972328	GOA
NOT located in peroxisome	IDA IDA: Inferred from direct assay	14972328	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MVD Protein Structure

GHMP_kinases_N

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

diphosphomevalonate decarboxylase

mevalonate (diphospho) decarboxylase

Related Diseases

Diseases

Alias

Porokeratosis 7, Multiple Types

POROK7

Porokeratosis 7, Disseminated Superficial Actinic Type

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Linear Porokeratosis

Congenital Facial Linear Porokeratosis

Porokeratosis, Linear

Scirrhous Adenocarcinoma

Adenocarcinoma, Scirrhous

Adenocarcinoma With Productive Fibrosis

Punctate Porokeratosis

Porokeratosis, Punctate

Keratoderma, Palmoplantar, Punctate Type Ii

Ck Syndrome

CKS	X-Linked Intellectual Disability-Microcephaly-Cortical Malformation-Thin Habitus Syndrome
Mental Retardation, X-Linked, With Thin Body Habitus And Cortical Malformation

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1596	Gluten Exorphin C	Inhibitor	98.97%	Unkown
HY-P3632	[DAla2, DArg6] Dynorphin A, (1-13) (porcine)		/	Unkown
HY-RS08856	MVD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MVD	VGNC	VGNC:31767
Canis familiaris	MVD	VGNC	VGNC:43508
Felis catus	MVD	VGNC	VGNC:68364
Rattus norvegicus	MVD	RGD	RGD:621292
Mus musculus	MVD	MGD	MGI:2179327
Macaca mulatta	MVD	VGNC	VGNC:82192

Name
Email *

	Sorry, but the email address you supplied was invalid.