MX2 - MX dynamin like GTPase 2 Gene

Homo sapiens

Also known as MXB

Gene ID: 4600 | Gene type: protein coding

About MX2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,362,027-41,409,393 (from NCBI)

This gene has 18 transcripts (splice variants), 102 orthologues and 6 paralogues. Broad expression in spleen (RPKM 16.5), appendix (RPKM 13.6) and 23 other tissues.

Summary

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the Dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the Antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

MX2 Products(1)

mRNA	Protein	Name
NM_002463.2	NP_002454.1	interferon-induced GTP-binding protein Mx2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IMP IMP: Inferred from mutant phenotype	15184662	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	24121441	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	15184662	GOA
involved in regulation of nucleocytoplasmic transport	IMP IMP: Inferred from mutant phenotype	15184662	GOA
involved in response to interferon-alpha	IDA IDA: Inferred from direct assay	24121441	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	24048477	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nuclear pore	IDA IDA: Inferred from direct assay	15184662	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MX2 Protein Structure

Dynamin_N

Dynamin_M

GED

0
200
400
600
715 a.a.

Protein Preferred Names

Protein Names

interferon-induced GTP-binding protein Mx2

interferon-regulated resistance GTP-binding protein MXB

MX2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MX2	P20592	EHMT2	Homo sapiens	A2ABF9	Validated Y2H	25416956
Intra	MX2	P20592	EHMT2	Homo sapiens	A2ABF9	Y2H Prey Pooling	25416956
Intra	MX2	P20592	PIAS2	Homo sapiens	O75928	Validated Y2H	25416956
Intra	MX2	P20592	PIAS2	Homo sapiens	O75928	Y2H Prey Pooling	25416956
Intra	MX2	P20592	EHMT2	Homo sapiens	Q96KQ7	Y2H Prey Pooling	32296183
Intra	MX2	P20592	EHMT2	Homo sapiens	Q96KQ7	Validated Y2H	32296183
Intra	MX2	P20592	EHMT2	Homo sapiens	Q96KQ7	Y2H Array	32296183
Intra	MX2	P20592	ATRIP	Homo sapiens	Q8WXE1	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Pediculus Humanus Corporis Infestation

Body Louse Infestation	Pediculus Corporis
Pediculus Humanus Infestation

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08860	MX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MX2	VGNC	VGNC:43512
Macaca mulatta	MX2	VGNC	VGNC:81723
Bos taurus	MX2	VGNC	VGNC:50221
Others	MX2	NCBI

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