PIAS2 - protein inhibitor of activated STAT 2 Gene

Homo sapiens

Also known as DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4

Gene ID: 9063 | Gene type: protein coding

About PIAS2

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:46,803,218-46,920,145 (from NCBI)

This gene has 16 transcripts (splice variants), 219 orthologues and 5 paralogues. Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues.

Summary

This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 Ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the Androgen Receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]

PIAS2 Products(22)

mRNA	Protein	Name
NM_001324046.2	NP_001310975.1	E3 SUMO-protein ligase PIAS2 isoform 4
NM_001324047.2	NP_001310976.1	E3 SUMO-protein ligase PIAS2 isoform 5
NM_001324048.2	NP_001310977.1	E3 SUMO-protein ligase PIAS2 isoform 6
NM_001324049.2	NP_001310978.1	E3 SUMO-protein ligase PIAS2 isoform 6
NM_001324051.2	NP_001310980.1	E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324052.2	NP_001310981.1	E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324053.2	NP_001310982.1	E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324054.2	NP_001310983.1	E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324055.2	NP_001310984.1	E3 SUMO-protein ligase PIAS2 isoform 8
NM_001324057.2	NP_001310986.1	E3 SUMO-protein ligase PIAS2 isoform 8
NM_001324058.2	NP_001310987.1	E3 SUMO-protein ligase PIAS2 isoform 9
NM_001324059.2	NP_001310988.1	E3 SUMO-protein ligase PIAS2 isoform 8
NM_001324060.2	NP_001310989.1	E3 SUMO-protein ligase PIAS2 isoform NY
NM_001354033.2	NP_001340962.1	E3 SUMO-protein ligase PIAS2 isoform 7
NM_001354034.2	NP_001340963.1	E3 SUMO-protein ligase PIAS2 isoform 10
NM_001354035.2	NP_001340964.1	E3 SUMO-protein ligase PIAS2 isoform 6
NM_001354036.2	NP_001340965.1	E3 SUMO-protein ligase PIAS2 isoform 6
NM_001354037.2	NP_001340966.1	E3 SUMO-protein ligase PIAS2 isoform 8
NM_001354038.2	NP_001340967.1	E3 SUMO-protein ligase PIAS2 isoform 5
NM_001354039.2	NP_001340968.1	E3 SUMO-protein ligase PIAS2 isoform 5
NM_004671.5	NP_004662.2	E3 SUMO-protein ligase PIAS2 isoform beta
NM_173206.4	NP_775298.1	E3 SUMO-protein ligase PIAS2 isoform alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20408817	GOA
enables SUMO ligase activity	IDA IDA: Inferred from direct assay	18579533	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	12393906	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11477070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	16777850	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20408817	GOA
involved in negative regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	11477070	GOA
involved in protein sumoylation	IDA IDA: Inferred from direct assay	20408817	GOA
NOT involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16777850	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with PML body	IDA IDA: Inferred from direct assay	22406621	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11477070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIAS2 Protein Structure

PINIT

zf-MIZ

0
100
200
300
400
500
621 a.a.

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase PIAS2

DAB2-interacting protein

PIAS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PIAS2	O75928	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	PIAS2	O75928	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	PIAS2	O75928	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	25416956
Intra	PIAS2	O75928	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	25416956
Intra	PIAS2	O75928	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	25416956
Intra	PIAS2	O75928	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	25416956
Intra	PIAS2	O75928	MX2	Homo sapiens	P20592	Y2H Array	25416956
Intra	PIAS2	O75928	q59gp6_human	Homo sapiens	Q59GP6	Y2H Prey Pooling	25416956
Intra	PIAS2	O75928	PRKAB2	Homo sapiens	O43741	Y2H Array	25416956
Intra	PIAS2	O75928	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	PIAS2	O75928	RACK1	Homo sapiens	P63244	Anti Bait CoIP	22210188
Intra	PIAS2	O75928	ACY3	Homo sapiens	Q96HD9	Y2H Array	25416956
Intra	PIAS2	O75928	RUFY1	Homo sapiens	Q96T51	Anti Tag CoIP	21988832
Intra	PIAS2	O75928	RUFY1	Homo sapiens	Q96T51	Y2H	21988832
Intra	PIAS2	O75928	MYC	Homo sapiens	P01106	Anti Bait CoIP	17418410
Intra	PIAS2	O75928	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	PIAS2	O75928	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	PIAS2	O75928	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	PIAS2	O75928	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	PIAS2	O75928	NAV2	Homo sapiens	Q8IVL1	Y2H Pooling	16189514
Intra	PIAS2	O75928	NAV2	Homo sapiens	Q8IVL1	Y2H Prey Pooling	25416956
Intra	PIAS2	O75928	NAV2	Homo sapiens	Q8IVL1	Validated Y2H	25416956
Intra	PIAS2	O75928	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	25416956
Intra	PIAS2	O75928	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	PIAS2	O75928	TSR2	Homo sapiens	Q969E8	Validated Y2H	25416956
Intra	PIAS2	O75928	TSR2	Homo sapiens	Q969E8	Y2H Array	25416956
Intra	PIAS2	O75928	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	PIAS2	O75928	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	25416956
Intra	PIAS2	O75928	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	25416956
Intra	PIAS2	O75928	SUMO1	Homo sapiens	P63165	Y2H Array	25416956
Intra	PIAS2	O75928	SUMO1	Homo sapiens	P63165	ITC	16204249
Intra	PIAS2	O75928	UBE2I	Homo sapiens	P63279	Y2H	19549727
Intra	PIAS2	O75928	UBE2I	Homo sapiens	P63279	Y2H Pooling	20936779
Intra	PIAS2	O75928	UBE2I	Homo sapiens	P63279	Confocal	21988832
Intra	PIAS2	O75928	UBE2I	Homo sapiens	P63279	Y2H	21988832
Intra	PIAS2	O75928	UBE2I	Homo sapiens	P63279	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10474	PIAS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PIAS2	VGNC	VGNC:75815
Bos taurus	PIAS2	VGNC	VGNC:97299
Canis familiaris	PIAS2	VGNC	VGNC:44520
Felis catus	PIAS2	VGNC	VGNC:82550
Rattus norvegicus	PIAS2	RGD	RGD:71056
Mus musculus	PIAS2	MGD	MGI:1096566

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