2. Gene
  3. PIAS2 - protein inhibitor of activated STAT 2 Gene

PIAS2 - protein inhibitor of activated STAT 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4

Gene ID: 9063 | Gene type: protein coding

About PIAS2

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:46,803,218-46,920,145 (from NCBI)

This gene has 16 transcripts (splice variants), 219 orthologues and 5 paralogues. Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues.

Summary

This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 Ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the Androgen Receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]

PIAS2 Products(22)

mRNA Protein Name
NM_001324046.2 NP_001310975.1 E3 SUMO-protein ligase PIAS2 isoform 4
NM_001324047.2 NP_001310976.1 E3 SUMO-protein ligase PIAS2 isoform 5
NM_001324048.2 NP_001310977.1 E3 SUMO-protein ligase PIAS2 isoform 6
NM_001324049.2 NP_001310978.1 E3 SUMO-protein ligase PIAS2 isoform 6
NM_001324051.2 NP_001310980.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324052.2 NP_001310981.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324053.2 NP_001310982.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324054.2 NP_001310983.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001324055.2 NP_001310984.1 E3 SUMO-protein ligase PIAS2 isoform 8
NM_001324057.2 NP_001310986.1 E3 SUMO-protein ligase PIAS2 isoform 8
NM_001324058.2 NP_001310987.1 E3 SUMO-protein ligase PIAS2 isoform 9
NM_001324059.2 NP_001310988.1 E3 SUMO-protein ligase PIAS2 isoform 8
NM_001324060.2 NP_001310989.1 E3 SUMO-protein ligase PIAS2 isoform NY
NM_001354033.2 NP_001340962.1 E3 SUMO-protein ligase PIAS2 isoform 7
NM_001354034.2 NP_001340963.1 E3 SUMO-protein ligase PIAS2 isoform 10
NM_001354035.2 NP_001340964.1 E3 SUMO-protein ligase PIAS2 isoform 6
NM_001354036.2 NP_001340965.1 E3 SUMO-protein ligase PIAS2 isoform 6
NM_001354037.2 NP_001340966.1 E3 SUMO-protein ligase PIAS2 isoform 8
NM_001354038.2 NP_001340967.1 E3 SUMO-protein ligase PIAS2 isoform 5
NM_001354039.2 NP_001340968.1 E3 SUMO-protein ligase PIAS2 isoform 5
NM_004671.5 NP_004662.2 E3 SUMO-protein ligase PIAS2 isoform beta
NM_173206.4 NP_775298.1 E3 SUMO-protein ligase PIAS2 isoform alpha
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20408817 GOA
enables SUMO ligase activity IDA
IDA: Inferred from direct assay
18579533 GOA
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
12393906 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11477070 GOA
Biological Process GO Annotation Evidence Reference Source
NOT involved in SMAD protein signal transduction IDA
IDA: Inferred from direct assay
16777850 GOA
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20408817 GOA
involved in negative regulation of androgen receptor signaling pathway IDA
IDA: Inferred from direct assay
11477070 GOA
involved in protein sumoylation IDA
IDA: Inferred from direct assay
20408817 GOA
NOT involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
16777850 GOA
Cellular Component GO Annotation Evidence Reference Source
colocalizes with PML body IDA
IDA: Inferred from direct assay
22406621 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11477070 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIAS2 Protein Structure

PINIT

PINIT: PINIT domain (141 - 297)

zf-MIZ

zf-MIZ: MIZ/SP-RING zinc finger (342 - 390)

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  • 621 a.a.
Protein Preferred Names Protein Names

E3 SUMO-protein ligase PIAS2

DAB2-interacting protein

Related Diseases

Diseases Alias
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10474 PIAS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PIAS2 VGNC VGNC:75815
Bos taurus PIAS2 VGNC VGNC:97299
Canis familiaris PIAS2 VGNC VGNC:44520
Felis catus PIAS2 VGNC VGNC:82550
Rattus norvegicus PIAS2 RGD RGD:71056
Mus musculus PIAS2 MGD MGI:1096566