NACA - nascent polypeptide associated complex subunit alpha Gene

Homo sapiens

Also known as HSD48; NACA1; skNAC; NAC-alpha

Gene ID: 4666 | Gene type: protein coding

About NACA

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,712,427-56,725,299 (from NCBI)

This gene has 26 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 75 phenotypes. Ubiquitous expression in ovary (RPKM 104.2), bone marrow (RPKM 62.0) and 25 other tissues.

Summary

This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]

NACA Products(7)

mRNA	Protein	Name
NM_001113201.3	NP_001106672.1	nascent polypeptide-associated complex subunit alpha isoform b
NM_001113202.2	NP_001106673.1	nascent polypeptide-associated complex subunit alpha isoform b
NM_001113203.3	NP_001106674.2	nascent polypeptide-associated complex subunit alpha isoform a
NM_001320193.2	NP_001307122.1	nascent polypeptide-associated complex subunit alpha isoform b
NM_001320194.2	NP_001307123.1	nascent polypeptide-associated complex subunit alpha isoform c
NM_001365896.1	NP_001352825.1	nascent polypeptide-associated complex subunit alpha isoform d
NM_005594.6	NP_005585.1	nascent polypeptide-associated complex subunit alpha isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein localization to endoplasmic reticulum	IDA IDA: Inferred from direct assay	10982809	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10982809	GOA
part of nascent polypeptide-associated complex	IPI IPI: Inferred from physical interaction	20214399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NACA Protein Structure

NAC

0
100
200
215 a.a.

Protein Preferred Names

Protein Names

nascent polypeptide-associated complex subunit alpha

alpha-NAC, muscle-specific form

NACA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NACA	Q13765	TXLNA	Homo sapiens	P40222	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Skeletal Muscle Neoplasm

Tumor Of Skeletal Muscle

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101044	PPADS tetrasodium		≥95.0%	Unkown
HY-A0236A	Aprindine hydrochloride	Inhibitor	98.96%	Unkown
HY-128678	ORM-10103	Inhibitor	99.97%	Unkown
HY-164684	Dichlorobenzamil	Inhibitor	/	Unkown
HY-RS08999	NACA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09000	NACA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NACA	RGD	RGD:1308642
Mus musculus	NACA	MGD	MGI:106095

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