NARS1 - asparaginyl-tRNA synthetase 1 Gene

Homo sapiens

Also known as NARS; ASNRS; NEDMILG; NEDMILEG

Gene ID: 4677 | Gene type: protein coding

About NARS1

Cytogenetic location: 18q21.31 Genomic coordinates (GRCh38): 18:57,600,656-57,621,836 (from NCBI)

This gene has 12 transcripts (splice variants), 233 orthologues, 4 paralogues and is associated with 4 phenotypes. Ubiquitous expression in thyroid (RPKM 64.3), kidney (RPKM 57.0) and 25 other tissues.

Summary

Aminoacyl-tRNA synthetases are a class of Enzymes that charge tRNAs with their cognate Amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

NARS1 Products(1)

mRNA	Protein	Name
NM_004539.4	NP_004530.1	asparagine--tRNA ligase, cytoplasmic

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables CCR3 chemokine receptor binding	IDA IDA: Inferred from direct assay	30171954	GOA
enables asparagine-tRNA ligase activity	IMP IMP: Inferred from mutant phenotype	9421509	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables protein dimerization activity	IDA IDA: Inferred from direct assay	9421509	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in asparaginyl-tRNA aminoacylation	IDA IDA: Inferred from direct assay	9421509	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	9421509	GOA
involved in cerebral cortex development	IMP IMP: Inferred from mutant phenotype	32788587	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NARS1 Protein Structure

tRNA_anti-codon

tRNA-synt_2

0
100
200
300
400
500
548 a.a.

Protein Preferred Names

Protein Names

asparagine--tRNA ligase, cytoplasmic

asparagine tRNA ligase 1, cytoplasmic

NARS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NARS1	O43776	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	NARS1	O43776	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	NARS1	O43776	ATXN1	Homo sapiens	P54253	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NARS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74738	NARS Protein, Human (sf9, His)	O43776 (M1-P548)	≥95%

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities

NEDMILEG

Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities, Autosomal Dominant

Neurodevelopmental Disorder With Microcephaly, Impaired Language, And Gait Abnormalities

NEDMILG

Neurodevelopmental Disorder With Microcephaly, Impaired Language, And Gait Abnormalities, Autosomal Recessive

Mitochondrial Complex I Deficiency, Nuclear Type 35

MC1DN35	Mitochondrial Complex 1 Deficiency, Nuclear Type 35
Nuclear Type Mitochondrial Complex I Deficiency 35

Myositis

Idiopathic Inflammatory Myopathy	Idiopathic Inflammatory Myositis
Iim	Imm
Idiopathic Inflammatory Myopathies	Myopathy, Familial Idiopathic Inflammatory
Inflammatory Disorder Of Muscle	Idiopathic Inflammatory Myopathy, Familial
Inflammatory Myopathy, Idiopathic	Myopathies Idiopathic Inflammatory
Familial Idiopathic Inflammatory Myopathy

Interstitial Lung Disease

Ild	Lung Diseases, Interstitial
Lung Diseases Interstitial	Interstitial Lung Diseases

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Deafness, Autosomal Recessive 94

DFNB94	Autosomal Recessive Nonsyndromic Deafness 94
Autosomal Recessive Deafness 94	Deafness, Autosomal Recessive, 94

Filarial Elephantiasis

Lymphatic Filariasis	Elephantiasis
Filariasis	Bancroftian Elephantiasis
Bancroftian Filarial Chyluria	Elephantiasis Of Eyelid
Bancroftian Filariasis	Elephantitis
Malayi Tropical Eosinphilia	Wuchereria Bancrofti Infection
Wuchereriasis	Elephantiasis, Filarial
Filarial Elephantiases	Infection By Wuchereria Bancrofti
Filarial Lymphangitis	Tropical Elephantiasis
Filarial Chylocele

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2996B	Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant)		/	Unkown
HY-RS09036	NARS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NARS1	RGD	RGD:1307238
Mus musculus	NARS1	MGD	MGI:1917473
Felis catus	NARS1	VGNC	VGNC:68416
Macaca mulatta	NARS1	VGNC	VGNC:75132
Canis familiaris	NARS1	VGNC	VGNC:43625
Others	NARS1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.