RPL10A - ribosomal protein L10a Gene

Homo sapiens

Also known as L10A; CSA19; NEDD6; Csa-19

Gene ID: 4736 | Gene type: protein coding

About RPL10A

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,468,401-35,470,780 (from NCBI)

This gene has 5 transcripts (splice variants), 160 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 957.8), bone marrow (RPKM 440.0) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL10A Products(1)

mRNA	Protein	Name
NM_007104.5	NP_009035.3	60S ribosomal protein L10a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24725412	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	25957688	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL10A Protein Structure

Ribosomal_L1

0
100
200
217 a.a.

Protein Preferred Names

Protein Names

60S ribosomal protein L10a

NEDD-6

RPL10A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPL10A	P62906	RPS3A	Homo sapiens	P61247	Anti Tag CoIP	33961781
Intra	RPL10A	P62906	RPL11	Homo sapiens	P62913	Crosslink	30021884
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Validated Y2H	25416956
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Validated Y2H	32296183
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Y2H Array	32296183
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Y2H Prey Pooling	25416956
Intra	RPL10A	P62906	RGS17	Homo sapiens	Q9UGC6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RPL10A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82135	RPL10A Antibody (YA1880)	WB	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12161	RPL10A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL10A	RGD	RGD:620497
Macaca mulatta	RPL10A	VGNC	VGNC:83460
Felis catus	RPL10A	VGNC	VGNC:105242
Mus musculus	RPL10A	MGD	MGI:1343877
Bos taurus	RPL10A	VGNC	VGNC:54233
Canis familiaris	RPL10A	VGNC	VGNC:105240

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