NFRKB - nuclear factor related to kappaB binding protein Gene

Homo sapiens

Also known as INO80G

Gene ID: 4798 | Gene type: protein coding

About NFRKB

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:129,863,636-129,895,578 (from NCBI)

This gene has 12 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 11.1), ovary (RPKM 7.8) and 25 other tissues.

Summary

Enables protease binding activity. Predicted to be involved in DNA recombination and DNA repair. Located in nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

NFRKB Products(2)

mRNA	Protein	Name
NM_001143835.2	NP_001137307.1	nuclear factor related to kappa-B-binding protein isoform 1
NM_006165.4	NP_006156.2	nuclear factor related to kappa-B-binding protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	18922472	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18922472	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	21303910	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27641337	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of DNA strand elongation	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	26340092	GOA
involved in regulation of chromosome organization	IMP IMP: Inferred from mutant phenotype	26340092	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Ino80 complex	IDA IDA: Inferred from direct assay	18922472	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18922472	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFRKB Protein Structure

NFRKB_winged

0
200
400
600
800
1000
1200
1299 a.a.

Protein Preferred Names

Protein Names

nuclear factor related to kappa-B-binding protein

DNA-binding protein R kappa B

NFRKB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NFRKB	Q6P4R8	UCHL5	Homo sapiens	Q9Y5K5	Y2H Array	25416956
Intra	NFRKB	Q6P4R8	UCHL5	Homo sapiens	Q9Y5K5	Pull Down	18922472
Intra	NFRKB	Q6P4R8	UCHL5	Homo sapiens	Q9Y5K5	Y2H	18922472
Intra	NFRKB	Q6P4R8	UCHL5	Homo sapiens	Q9Y5K5-3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09266	NFRKB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NFRKB	RGD	RGD:1310558
Bos taurus	NFRKB	VGNC	VGNC:32051
Felis catus	NFRKB	VGNC	VGNC:68489
Mus musculus	NFRKB	MGD	MGI:2442410
Macaca mulatta	NFRKB	VGNC	VGNC:75343
Canis familiaris	NFRKB	VGNC	VGNC:43786

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