UCHL5 - ubiquitin C-terminal hydrolase L5 Gene

Homo sapiens

Also known as UCH37; CGI-70; INO80R; UCH-L5

Gene ID: 51377 | Gene type: protein coding

About UCHL5

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:193,012,254-193,060,076 (from NCBI)

This gene has 13 transcripts (splice variants), 213 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 5.2), esophagus (RPKM 3.6) and 25 other tissues.

Summary

Enables endopeptidase inhibitor activity; Proteasome binding activity; and thiol-dependent Deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

UCHL5 Products(17)

mRNA	Protein	Name
NM_001199261.3	NP_001186190.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2
NM_001199262.3	NP_001186191.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 3
NM_001199263.3	NP_001186192.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4
NM_001350840.2	NP_001337769.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 5
NM_001350841.2	NP_001337770.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 6
NM_001350842.2	NP_001337771.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 7
NM_001350843.2	NP_001337772.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 8
NM_001350844.2	NP_001337773.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 9
NM_001350845.2	NP_001337774.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 10
NM_001350846.2	NP_001337775.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 11
NM_001350847.2	NP_001337776.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 12
NM_001350848.2	NP_001337777.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13
NM_001350849.2	NP_001337778.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13
NM_001350850.2	NP_001337779.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14
NM_001350851.2	NP_001337780.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14
NM_001350852.2	NP_001337781.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 15
NM_015984.5	NP_057068.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	18922472	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	28992318	GOA
enables endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	18162577	GOA
enables proteasome binding	IDA IDA: Inferred from direct assay	18162577	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11163772	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	21303910	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23770237	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27641337	GOA
involved in positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	28992318	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	18922472	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of DNA strand elongation	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	26340092	GOA
involved in regulation of chromosome organization	IMP IMP: Inferred from mutant phenotype	26340092	GOA
involved in regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	18162577	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Ino80 complex	IDA IDA: Inferred from direct assay	18922472	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18922472	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18922472	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCHL5 Protein Structure

Peptidase_C12

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase isozyme L5

INO80 complex subunit R

UCHL5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UCHL5	Q9Y5K5	TFPT	Homo sapiens	P0C1Z6	Anti Tag CoIP	19615732
Intra	UCHL5	Q9Y5K5	TFPT	Homo sapiens	P0C1Z6	Anti Tag CoIP	18922472
Intra	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Anti Tag CoIP	33961781
Intra	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Anti Tag CoIP	18922472
Intra	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Y2H Prey Pooling	25416956
Intra	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Validated Y2H	25416956
Intra	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Anti Tag CoIP	19615732
Intra	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Pull Down	18922472
Intra	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	19490896
Intra	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	18922472
Intra	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	19615732
Intra	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	16990800
Intra	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	33961781
Intra	UCHL5	Q9Y5K5	PSMA6	Homo sapiens	P60900	Anti Tag CoIP	19490896
Intra	UCHL5	Q9Y5K5	PSMA6	Homo sapiens	P60900	Anti Tag CoIP	18922472
Intra	UCHL5	Q9Y5K5	PSMA6	Homo sapiens	P60900	Anti Tag CoIP	16990800
Intra	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	19615732
Intra	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	33961781
Intra	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Pull Down	17139257
Intra	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	19490896
Intra	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	18922472
Intra	UCHL5	Q9Y5K5	INO80E	Homo sapiens	Q8NBZ0	Anti Tag CoIP	18922472
Intra	UCHL5	Q9Y5K5	INO80E	Homo sapiens	Q8NBZ0	Anti Tag CoIP	19615732
Intra	UCHL5	Q9Y5K5	ACTR8	Homo sapiens	Q9H981	Anti Tag CoIP	33961781
Intra	UCHL5	Q9Y5K5	ACTR8	Homo sapiens	Q9H981	Anti Tag CoIP	18922472
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	33961781
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Y2H	21516116
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Pull Down	17139257
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Density Sedimentation	16990800
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	18922472
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Y2H Prey Pooling	25416956
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	19615732
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Validated Y2H	25416956
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	19490896
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Pull Down	16990800
Intra	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	16990800

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13989	b-AP15		98.57%	Unkown
HY-149230	USP28-IN-4	Inhibitor	99.35%	Unkown
HY-149229	USP28-IN-3	Inhibitor	98.26%	Unkown
HY-149228	USP28-IN-2	Inhibitor	/	Unkown
HY-164689	Cadmium pyrithione	Inhibitor	/	Unkown
HY-RS15402	UCHL5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UCHL5	VGNC	VGNC:97678
Canis familiaris	UCHL5	VGNC	VGNC:48105
Mus musculus	UCHL5	MGD	MGI:1914848
Bos taurus	UCHL5	VGNC	VGNC:36633
Rattus norvegicus	UCHL5	RGD	RGD:1305414
Macaca mulatta	UCHL5	VGNC	VGNC:79197
Others	UCHL5	NCBI

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