ATP1B3 - ATPase Na+/K+ transporting subunit beta 3 Gene

Homo sapiens

Also known as CD298; ATPB-3

Gene ID: 483 | Gene type: protein coding

About ATP1B3

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:141,876,643-141,926,549 (from NCBI)

This gene has 10 transcripts (splice variants), 283 orthologues and 4 paralogues. Ubiquitous expression in adrenal (RPKM 108.4), skin (RPKM 99.2) and 22 other tissues.

Summary

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This Enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

ATP1B3 Products(1)

mRNA	Protein	Name
NM_001679.4	NP_001670.1	sodium/potassium-transporting ATPase subunit beta-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	10636900	GOA
enables ATPase binding	IPI IPI: Inferred from physical interaction	10636900	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	10636900	GOA
enables protein-macromolecule adaptor activity	IGI IGI: Inferred from genetic interaction	16861705	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular potassium ion homeostasis	IDA IDA: Inferred from direct assay	10636900	GOA
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	10636900	GOA
involved in membrane repolarization	IDA IDA: Inferred from direct assay	19542013	GOA
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of potassium ion import across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of potassium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of sodium ion export across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in potassium ion import across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in potassium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	16861705	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	18522992	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	10636900	GOA
involved in sodium ion export across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in sodium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	16861705	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	18522992	GOA
part of sodium:potassium-exchanging ATPase complex	IDA IDA: Inferred from direct assay	10636900	GOA
part of sodium:potassium-exchanging ATPase complex	IPI IPI: Inferred from physical interaction	16861705	GOA
located in sperm flagellum	IDA IDA: Inferred from direct assay	16861705	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP1B3 Protein Structure

Na_K-ATPase

0
100
200
279 a.a.

Protein Preferred Names

Protein Names

sodium/potassium-transporting ATPase subunit beta-3

ATPase, Na+/K+ transporting, beta 3 polypeptide

ATP1B3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATP1B3	P54709	SMAGP	Homo sapiens	Q0VAQ4	Validated Y2H	32296183
Intra	ATP1B3	P54709	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	ATP1B3	P54709	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	ATP1B3	P54709	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	ATP1B3	P54709	TMEM98	Homo sapiens	Q9Y2Y6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Newfoundland Rod-Cone Dystrophy

Newfoundland Cone-Rod Dystrophy	NFRCD
Rod-Cone Dystrophy Newfoundland

Petroclival Meningioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01188	ATP1B3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ATP1B3	VGNC	VGNC:26287
Canis familiaris	ATP1B3	VGNC	VGNC:38250
Rattus norvegicus	ATP1B3	RGD	RGD:2172
Mus musculus	ATP1B3	MGD	MGI:107788
Macaca mulatta	ATP1B3	VGNC	VGNC:110383
Felis catus	ATP1B3	VGNC	VGNC:68595

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