1. Gene
  2. NPY1R - neuropeptide Y receptor Y1 Gene

NPY1R - neuropeptide Y receptor Y1 Gene

Homo sapiens

Also known as NPYR; NPY1-R

Gene ID: 4886 | Gene type: protein coding

About NPY1R

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,323,962-163,344,689 (from NCBI)

This gene has 7 transcripts (splice variants), 145 orthologues and 33 paralogues. Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues.

Summary

This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of Adenylate Cyclase activity. [provided by RefSeq, Aug 2013]

NPY1R Products(3)

mRNA Protein Name
NM_000909.6 NP_000900.1 neuropeptide Y receptor type 1
XM_005263031.5 XP_005263088.1 neuropeptide Y receptor type 1 isoform X1
XM_011532010.4 XP_011530312.1 neuropeptide Y receptor type 1 isoform X1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23597562 GOA
Biological Process GO Annotation Evidence Reference Source
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19593212 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPY1R Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (57 - 320)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

neuropeptide Y receptor type 1

NPY1R Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NPY1R P25929 PYY Homo sapiens P10082
SPA
23597562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pelvic Organ Prolapse

Rectal Prolapse

Pelvic Organ Prolapse, Susceptibility To

Pelvic Organ Prolapse, Susceptibility To, 1

Prolapse Of Vagina And Rectum

Vaginal Prolapse

Pelvic Organ Prolapse 1

Procidentia, Rectum

Prolapse Of Rectal Mucosa

Procidentia Of Rectum

Rectal Mucosa Prolapse

Rectum Prolapse

Procidentia Rectum

Rp - [Rectal Prolapse]

Male Proctocele

Male Rectocele

Proctoptosis

Female Genital Prolapse

Female Prolapse

Incompetence Of Pelvic Fundus

Relaxation Of Perineum

Deficiency Of Perineum

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta NPY1R VGNC VGNC:75394
Felis catus NPY1R VGNC VGNC:78537
Rattus norvegicus NPY1R RGD RGD:3198
Mus musculus NPY1R MGD MGI:104963
Bos taurus NPY1R VGNC VGNC:32223
Canis familiaris NPY1R VGNC VGNC:43937
Others NPY1R NCBI