NPY2R - neuropeptide Y receptor Y2 Gene

Homo sapiens

Also known as NPY2-R

Gene ID: 4887 | Gene type: protein coding

About NPY2R

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,173,723-155,217,076 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 33 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable Calcium Channel regulator activity and Neuropeptide Y Receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Apr 2022]

NPY2R Products(3)

mRNA	Protein	Name
NM_001375470.1	NP_001362399.1	neuropeptide Y receptor type 2
NM_001370180.1	NP_001357109.1	neuropeptide Y receptor type 2
NM_000910.4	NP_000901.1	neuropeptide Y receptor type 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23597562	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	19593212	GOA
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19593212	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPY2R Protein Structure

7tm_1

0
100
200
300
381 a.a.

Protein Preferred Names

Protein Names

neuropeptide Y receptor type 2

NPY-Y2 receptor

NPY2R Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NPY2R	P49146	PYY	Homo sapiens	P10082	SPA	23597562

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nephronophthisis 4

NPHP4	Juvenile Nephronophthisis 4
Nephronophthisis 4, Juvenile	Nephronophthisis, Type 4

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Peripheral Artery Disease

Peripheral Arterial Disease

Peripheral Arterial Diseases

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Huntington Disease

Huntington'S Disease	Huntington Chorea
HD	Huntington'S Chorea
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101986	BIIE-0246	Antagonist	99.10%	Unkown
HY-101986A	BIIE-0246 hydrochloride	Antagonist	≥99.0%	Unkown
HY-RS09514	NPY2R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09515	Npy2r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09516	NPY2R Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NPY2R	MGD	MGI:108418
Rattus norvegicus	NPY2R	RGD	RGD:620475
Felis catus	NPY2R	VGNC	VGNC:78538
Macaca mulatta	NPY2R	VGNC	VGNC:100257
Bos taurus	NPY2R	VGNC	VGNC:52806
Others	NPY2R	NCBI

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