2. Gene
  3. NTSR1 - neurotensin receptor 1 Gene

NTSR1 - neurotensin receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NTR

Gene ID: 4923 | Gene type: protein coding

About NTSR1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,708,836-62,762,771 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

Neurotensin Receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]

NTSR1 Products(1)

mRNA Protein Name
NM_002531.3 NP_002522.2 neurotensin receptor type 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled neurotensin receptor activity IDA
IDA: Inferred from direct assay
21725197 GOA
enables G protein-coupled neurotensin receptor activity IMP
IMP: Inferred from mutant phenotype
8381365 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17620610 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17620610 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21725197 GOA
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
21725197 GOA
involved in neuropeptide signaling pathway IGI
IGI: Inferred from genetic interaction
21806946 GOA
acts upstream of positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
21806946 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane raft IDA
IDA: Inferred from direct assay
21725197 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
8381365 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTSR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (80 - 364)

  • 0
  • 100
  • 200
  • 300
  • 418 a.a.
Protein Preferred Names Protein Names

neurotensin receptor type 1

NT-R-1

NTR1

NTRH

high-affinity levocabastine-insensitive neurotensin receptor

neurotensin receptor 1 (high affinity)

NTSR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NTSR1 P30989 NTS Homo sapiens P30990
Light Scattering
17620610
Intra
NTSR1 P30989 NTSR1 Homo sapiens P30989
Light Scattering
17620610
Intra
NTSR1 P30989 NTSR1 Homo sapiens P30989
GMS
17620610
Intra
NTSR1 P30989 NTS Homo sapiens P30990
GMS
17620610
Intra
NTSR1 P30989 P30990-PRO_0000019524 Homo sapiens P30990-PRO_0000019524
SPA
23597562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trigeminal Nerve Neoplasm

Neoplasm Of Trigeminal Nerve

Tumor Of Trigeminal Nerve
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Brain Stem Medulloblastoma
Jugular Foramen Meningioma

Meningioma Of The Jugular Foramen
Acute Flaccid Myelitis
Paralytic Poliomyelitis

Poliomyelitis, Paralytic
Schwannoma Of Twelfth Cranial Nerve

Hypoglossal Schwannoma

Schwannoma Of The Twelfth Cranial Nerve
Suprasellar Meningioma
Hypoglossal Nerve Disease

Hypoglossal Nerve Diseases

Disorder Of 12th Nerve

Disorder Of Hypoglossal [12th] Nerve

Disorder Of Hypoglossal Nerve

Disorder Of Xii Nerve

Disorders Of The Twelfth Cranial Nerve

Disorders Of 12th Cranial Nerve
Petrous Apex Meningioma

Meningioma Of The Petrous Ridge
Neurilemmoma Of The Fifth Cranial Nerve

Trigeminal Schwannoma

Trigeminal Neurilemmoma
Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125880 SBI-553 Modulator 99.73% Unkown
HY-RS09638 NTSR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-164795 SBI-810 Modulator / Unkown
HY-164795A SBI-810 hydrochloride Modulator 99.11% Unkown
HY-P10698 VH-N412 / Unkown
HY-RS09639 Ntsr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09640 Ntsr1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NTSR1 RGD RGD:1306076
Canis familiaris NTSR1 VGNC VGNC:44014
Bos taurus NTSR1 VGNC VGNC:32312
Felis catus NTSR1 VGNC VGNC:68582
Mus musculus NTSR1 MGD MGI:97386
Macaca mulatta NTSR1 VGNC VGNC:75544
Macaca fascicularis NTSR1 NCBI NCBI:102115340
Others NTSR1 NCBI