NUP88 - nucleoporin 88 Gene

Homo sapiens

Also known as FADS4

Gene ID: 4927 | Gene type: protein coding

About NUP88

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,384,833-5,419,662 (from NCBI)

This gene has 33 transcripts (splice variants), 204 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 25.7), lymph node (RPKM 15.5) and 25 other tissues.

Summary

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

NUP88 Products(2)

mRNA	Protein	Name
NM_001320653.2	NP_001307582.1	nuclear pore complex protein Nup88 isoform 1
NM_002532.6	NP_002523.2	nuclear pore complex protein Nup88 isoform 2

NUP88 Protein Structure

Nup88

0
200
400
600
741 a.a.

Protein Preferred Names

Protein Names

nuclear pore complex protein Nup88

karyoporin

NUP88 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUP88	Q99567	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	NUP88	Q99567	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	NUP88	Q99567	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	NUP88	Q99567	NUP214	Homo sapiens	P35658	Anti Tag CoIP	33961781
Intra	NUP88	Q99567	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	NUP88	Q99567	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	NUP88	Q99567	NUP62	Homo sapiens	P37198	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fetal Akinesia Deformation Sequence 4

FADS4	Fetal Akinesia Deformation Sequence Syndrome 4
Akinesia, Fetal, Deformation Sequence, Type 4

Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence	Fads
Fetal Akinesia Sequence	FADS1
Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia	Pena-Shokeir Syndrome Type 1
Fetal Akinesia Deformation Sequence Syndrome	Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome
Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia	Pena-Shokeir Syndrome, Type I
Foetal Akinesia Deformation Sequence Syndrome	Foetal Akinesia Sequence
Fetal Akinesia Deformation Sequence Syndrome 1	Pena-Shokeir Syndrome, Type 1
Pena Shokeir Syndrome, Type 1	Akinesia, Fetal, Deformation Sequence
Akinesia, Fetal, Deformation Sequence, Type 1	Pena-Shokeir Syndrome Type I

Cranioectodermal Dysplasia 4

CED4	Sensenbrenner Syndrome 4
Dysplasia, Cranioectodermal, Type 4

Anterior Horn Cell Disease

Lethal Congenital Contracture Syndrome 1

LCCS1	Multiple Contracture Syndrome, Finnish Type
Lccs	Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures
Lethal Congenital Contracture Syndrome Type 1	Herva Disease
Multiple Contracture Syndrome Finnish Type	Contracture Syndrome, Lethal, Congenital, Type 1

Lethal Congenital Contracture Syndrome

Lccs	Lethal Congenital Contracture Syndrome 1

Polyhydramnios

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09699	NUP88 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NUP88	VGNC	VGNC:75562
Felis catus	NUP88	VGNC	VGNC:68600
Mus musculus	NUP88	MGD	MGI:104900
Canis familiaris	NUP88	VGNC	VGNC:44061
Rattus norvegicus	NUP88	RGD	RGD:620182
Bos taurus	NUP88	VGNC	VGNC:32365

Name
Email *

	Sorry, but the email address you supplied was invalid.