2. Gene
  3. TFIP11 - tuftelin interacting protein 11 Gene

TFIP11 - tuftelin interacting protein 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NTR1; STIP; TIP39; STIP-1; Spp382; bK445C9.6

Gene ID: 24144 | Gene type: protein coding

About TFIP11

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:26,491,240-26,512,473 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 20.2), bone marrow (RPKM 19.7) and 25 other tissues.

Summary

This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

TFIP11 Products(7)

mRNA Protein Name
NM_001008697.3 NP_001008697.1 tuftelin-interacting protein 11 isoform 1
NM_001346857.2 NP_001333786.1 tuftelin-interacting protein 11 isoform 1
NM_001346858.2 NP_001333787.1 tuftelin-interacting protein 11 isoform 1
NM_001346859.2 NP_001333788.1 tuftelin-interacting protein 11 isoform 1
NM_001346861.2 NP_001333790.1 tuftelin-interacting protein 11 isoform 1
NM_001346862.2 NP_001333791.1 tuftelin-interacting protein 11 isoform 2
NM_012143.4 NP_036275.1 tuftelin-interacting protein 11 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17043677 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
17389648 GOA
involved in negative regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
17389648 GOA
involved in spliceosomal complex disassembly IMP
IMP: Inferred from mutant phenotype
19103666 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U2-type post-mRNA release spliceosomal complex IDA
IDA: Inferred from direct assay
19103666 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
17389648 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
17389648 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
11991638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFIP11 Protein Structure

TIP_N

TIP_N: Tuftelin interacting protein N terminal (16 - 103)

G-patch

G-patch: G-patch domain (149 - 192)

GCFC

GCFC: GC-rich sequence DNA-binding factor-like protein (397 - 666)

  • 0
  • 200
  • 400
  • 600
  • 837 a.a.
Protein Preferred Names Protein Names

tuftelin-interacting protein 11

septin and tuftelin-interacting protein 1

Related Diseases

Diseases Alias
Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay
Dentine Erosion
Dental Fluorosis

Mottled Teeth

Intrinsic Enamel Discolouration Of Fluorosis

Mottling Of Enamel

Fluorosis, Dental

Dental Fluorosis, Acquired
Tooth Erosion

Generalized Erosion

Localized Erosion

Generalized Erosions

Erosion, Localized
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14426 TFIP11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TFIP11 VGNC VGNC:66123
Macaca mulatta TFIP11 VGNC VGNC:78399
Bos taurus TFIP11 VGNC VGNC:35793
Canis familiaris TFIP11 VGNC VGNC:47300
Mus musculus TFIP11 MGD MGI:1930075
Rattus norvegicus TFIP11 RGD RGD:1311449