OAZ1 - ornithine decarboxylase antizyme 1 Gene

Homo sapiens

Also known as AZ1; AZI; OAZ

Gene ID: 4946 | Gene type: protein coding

About OAZ1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,269,486-2,273,488 (from NCBI)

This gene has 11 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 404.8), lymph node (RPKM 286.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key Enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]

OAZ1 Products(2)

mRNA	Protein	Name
NM_001301020.1	NP_001287949.1	ornithine decarboxylase antizyme 1 isoform 2
NM_004152.3	NP_004143.1	ornithine decarboxylase antizyme 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28298427	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OAZ1 Protein Structure

ODC_AZ

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

ornithine decarboxylase antizyme 1

ODC-Az

OAZ1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OAZ1	P54368	AGTR1	Homo sapiens	P30556	Ub Reconstruction	28298427

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurofibromatosis-Noonan Syndrome

NFNS	Neurofibromatosis Type 1
Neurofibromatosis With Noonan Phenotype	Nf1
Von Recklinghausen Disease	Neurofibromatosis Type 1-Noonan Syndrome
Noonan Neurofibromatosis Syndrome	Recklinghausen'S Disease
Noonan-Neurofibromatosis Syndrome	Fibromatosis Multiple Non Ossifying
Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots	Jaffe Campanacci Syndrome
Type 1 Neurofibromatosis	Neurofibromatosis 1
Peripheral Neurofibromatosis	Recklinghausen Disease, Nerve
Jaffe-Campanacci Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09732	OAZ1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OAZ1	MGD	MGI:109433
Felis catus	OAZ1	VGNC	VGNC:102650
Bos taurus	OAZ1	VGNC	VGNC:55296
Rattus norvegicus	OAZ1	RGD	RGD:3219
Canis familiaris	OAZ1	VGNC	VGNC:81896
Macaca mulatta	OAZ1	VGNC	VGNC:97799

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