ATP4B - ATPase H+/K+ transporting subunit beta Gene

Homo sapiens

Also known as ATP6B

Gene ID: 496 | Gene type: protein coding

About ATP4B

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,648,804-113,658,198 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 171 orthologues and 4 paralogues. Restricted expression toward stomach (RPKM 286.6).

Summary

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This Enzyme is a Proton Pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

ATP4B Products(1)

mRNA	Protein	Name
NM_000705.4	NP_000696.1	potassium-transporting ATPase subunit beta

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP4B Protein Structure

Na_K-ATPase

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

potassium-transporting ATPase subunit beta

ATPase H+/K+ transporting beta subunit

Related Diseases

Diseases

Alias

Chronic Laryngitis

Myasthenic Syndrome, Congenital, 11, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 11	CMS11
Cms Ie	Cms1e
Myasthenic Syndrome, Congenital, Ie	Myasthenic Syndrome, Congenital, Ie, Formerly
Cms1e, Formerly	Cms Ie, Formerly
Congenital Myasthenic Syndrome 11 Associated With Acetylcholine Receptor Deficiency	Congenital Myasthenic Syndrome 1e
Myasthenic Syndrome, Congenital, Type 11, Associated With Acetylcholine Receptor Deficiency

Autoimmune Gastritis

Brain Small Vessel Disease 2

Porencephaly 2	BSVD2
Gould Syndrome 2	Porencephaly 2, Formerly
Poren2, Formerly	Poren2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01201	ATP4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ATP4B	VGNC	VGNC:106251
Rattus norvegicus	ATP4B	RGD	RGD:2178
Bos taurus	ATP4B	VGNC	VGNC:26298
Felis catus	ATP4B	VGNC	VGNC:68642
Mus musculus	ATP4B	MGD	MGI:88114
Canis familiaris	ATP4B	VGNC	VGNC:38263

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