GPR42 - G protein-coupled receptor 42 Gene

Homo sapiens

Also known as FFAR1L; FFAR3L; GPR41L; GPR42P

Gene ID: 2866 | Gene type: protein coding

About GPR42

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,371,068-35,372,962 (from NCBI)

This gene has 2 transcripts (splice variants), 339 orthologues and 15 paralogues.

Summary

Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR42 Products(1)

mRNA	Protein	Name
NM_001348195.2	NP_001335124.1	G-protein coupled receptor 42

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	12496283	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12496283	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR42 Protein Structure

7tm_1

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 42

G protein-coupled receptor 42 pseudogene

GPR42 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPR42	O15529	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM182	Homo sapiens	Q6ZP80	Validated Y2H	32296183
Intra	GPR42	O15529	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	GPR42	O15529	NRM	Homo sapiens	Q8IXM6	Y2H Array	32296183
Intra	GPR42	O15529	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	GPR42	O15529	CCL4L1	Homo sapiens	Q8NHW4	Validated Y2H	32296183
Intra	GPR42	O15529	SLC41A2	Homo sapiens	Q96JW4	Validated Y2H	32296183
Intra	GPR42	O15529	SLC30A3	Homo sapiens	Q99726	Validated Y2H	32296183
Intra	GPR42	O15529	DRAM1	Homo sapiens	Q8N682	Validated Y2H	32296183
Intra	GPR42	O15529	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	GPR42	O15529	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	GPR42	O15529	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	GPR42	O15529	TMBIM6	Homo sapiens	P55061	Validated Y2H	32296183
Intra	GPR42	O15529	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	GPR42	O15529	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	GPR42	O15529	ERMP1	Homo sapiens	Q7Z2K6	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	GPR42	O15529	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	GPR42	O15529	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	GPR42	O15529	ATP13A1	Homo sapiens	Q9HD20-3	Validated Y2H	32296183
Intra	GPR42	O15529	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	GPR42	O15529	LNPEP	Homo sapiens	Q9UIQ6-2	Validated Y2H	32296183
Intra	GPR42	O15529	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
Intra	GPR42	O15529	SYNGR1	Homo sapiens	O43759-2	Validated Y2H	32296183
Intra	GPR42	O15529	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
Intra	GPR42	O15529	PLP1	Homo sapiens	P60201-2	Y2H Array	32296183
Intra	GPR42	O15529	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	GPR42	O15529	STRIT1	Homo sapiens	P0DN84	Validated Y2H	32296183
Intra	GPR42	O15529	LTC4S	Homo sapiens	Q16873	Validated Y2H	32296183
Intra	GPR42	O15529	SLC41A1	Homo sapiens	Q8IVJ1	Validated Y2H	32296183
Intra	GPR42	O15529	NDUFB11	Homo sapiens	Q9NX14	Validated Y2H	32296183
Intra	GPR42	O15529	IL1RL1	Homo sapiens	Q01638-2	Validated Y2H	32296183
Intra	GPR42	O15529	SLC35E4	Homo sapiens	Q6ICL7	Validated Y2H	32296183
Intra	GPR42	O15529	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	GPR42	O15529	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	GPR42	O15529	EFNA5	Homo sapiens	P52803	Validated Y2H	32296183
Intra	GPR42	O15529	ITGAM	Homo sapiens	P11215	Validated Y2H	32296183
Intra	GPR42	O15529	SERINC1	Homo sapiens	Q9NRX5	Validated Y2H	32296183
Intra	GPR42	O15529	YIF1A	Homo sapiens	O95070	Validated Y2H	32296183
Intra	GPR42	O15529	MS4A1	Homo sapiens	P11836	Validated Y2H	32296183
Intra	GPR42	O15529	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	GPR42	O15529	MGAM	Homo sapiens	O43451	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	GPR42	O15529	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	GPR42	O15529	MFSD6	Homo sapiens	Q6ZSS7	Validated Y2H	32296183
Intra	GPR42	O15529	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	GPR42	O15529	GPR37L1	Homo sapiens	O60883	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	GPR42	O15529	COMT	Homo sapiens	P21964	Validated Y2H	32296183
Intra	GPR42	O15529	ATP6V0B	Homo sapiens	Q99437	Validated Y2H	32296183
Intra	GPR42	O15529	ATP4B	Homo sapiens	P51164	Validated Y2H	32296183
Intra	GPR42	O15529	ALOX5AP	Homo sapiens	P20292	Validated Y2H	32296183
Intra	GPR42	O15529	GJB2	Homo sapiens	P29033	Validated Y2H	32296183
Intra	GPR42	O15529	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	GPR42	O15529	CD300C	Homo sapiens	Q08708	Validated Y2H	32296183
Intra	GPR42	O15529	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	GPR42	O15529	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	GPR42	O15529	JPH1	Homo sapiens	Q9HDC5	Validated Y2H	32296183
Intra	GPR42	O15529	PAEP	Homo sapiens	P09466	Validated Y2H	32296183
Intra	GPR42	O15529	NSG1	Homo sapiens	P42857	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM65	Homo sapiens	Q6PI78	Validated Y2H	32296183
Intra	GPR42	O15529	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	GPR42	O15529	TF	Homo sapiens	P02787	Validated Y2H	32296183
Intra	GPR42	O15529	APOD	Homo sapiens	P05090	Validated Y2H	32296183
Intra	GPR42	O15529	ZFPL1	Homo sapiens	O95159	Validated Y2H	32296183
Intra	GPR42	O15529	IGFBP5	Homo sapiens	P24593	Validated Y2H	32296183
Intra	GPR42	O15529	ATP6V0C	Homo sapiens	P27449	Validated Y2H	32296183
Intra	GPR42	O15529	IER3IP1	Homo sapiens	Q9Y5U9	Validated Y2H	32296183
Intra	GPR42	O15529	SYNDIG1	Homo sapiens	Q9H7V2	Validated Y2H	32296183
Intra	GPR42	O15529	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	GPR42	O15529	STATH	Homo sapiens	P02808	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
Intra	GPR42	O15529	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	GPR42	O15529	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183
Intra	GPR42	O15529	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	GPR42	O15529	KLRG1	Homo sapiens	Q96E93	Validated Y2H	32296183
Intra	GPR42	O15529	LEPROTL1	Homo sapiens	O95214	Validated Y2H	32296183
Intra	GPR42	O15529	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	32296183
Intra	GPR42	O15529	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	GPR42	O15529	YIPF4	Homo sapiens	Q9BSR8	Validated Y2H	32296183
Intra	GPR42	O15529	GYPC	Homo sapiens	P04921	Validated Y2H	32296183
Intra	GPR42	O15529	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	GPR42	O15529	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	GPR42	O15529	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	GPR42	O15529	YIPF1	Homo sapiens	Q9Y548	Validated Y2H	32296183
Intra	GPR42	O15529	LAT	Homo sapiens	O43561-2	Validated Y2H	32296183
Intra	GPR42	O15529	KCNA1	Homo sapiens	Q09470	Validated Y2H	32296183
Intra	GPR42	O15529	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	GPR42	O15529	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	GPR42	O15529	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	GPR42	O15529	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183
Intra	GPR42	O15529	TM4SF4	Homo sapiens	P48230	Validated Y2H	32296183
Intra	GPR42	O15529	PNLIPRP1	Homo sapiens	P54315	Validated Y2H	32296183
Intra	GPR42	O15529	CCDC167	Homo sapiens	Q9P0B6	Validated Y2H	32296183
Intra	GPR42	O15529	TMEM30B	Homo sapiens	Q3MIR4	Validated Y2H	32296183
Intra	GPR42	O15529	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05715	GPR42 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GPR42	MGD	MGI:2685324

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